2. Gene
  3. Gjb2 - gap junction protein, beta 2 Gene

Gjb2 - gap junction protein, beta 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cx26; Cxne; Cnx26; Gjb-2

Gene ID: 14619 | Gene type: protein coding

About Gjb2

Summary

Enables gap junction channel activity. Involved in cell-cell signaling and gap junction-mediated intercellular transport. Acts upstream of or within gap junction assembly. Located in gap junction. Is integral component of plasma membrane. Part of connexin complex. Is expressed in several structures, including alimentary system; ear; genitourinary system; meninges; and skin. Used to study autosomal dominant keratitis-ichthyosis-deafness syndrome and autosomal recessive nonsyndromic deafness 1A. Human ortholog(s) of this gene implicated in Bart-Pumphrey syndrome; Vohwinkel syndrome; autosomal dominant keratitis-ichthyosis-deafness syndrome; nonsyndromic deafness (multiple); and palmoplantar keratoderma-deafness syndrome. Orthologous to human GJB2 (Gap Junction Protein beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Gjb2 Products(1)

mRNA Protein Name
NM_008125.3 NP_032151.1 gap junction beta-2 protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables gap junction channel activity IDA
IDA: Inferred from direct assay
15692151 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14595769 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cell-cell signaling IDA
IDA: Inferred from direct assay
15692151 MGI
acts upstream of or within gap junction assembly IMP
IMP: Inferred from mutant phenotype
24590285 MGI
involved in gap junction-mediated intercellular transport IDA
IDA: Inferred from direct assay
15692151 MGI
Cellular Component GO Annotation Evidence Reference Source
part of connexin complex IDA
IDA: Inferred from direct assay
15692151 MGI
located in gap junction IDA
IDA: Inferred from direct assay
14595769 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15692151 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gap junction beta-2 protein

connexin e

connexin-26

gap junction membrane channel protein beta 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05447 GJB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20742 Gjb2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27254 Gjb2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gjb2 NCBI NCBI:2706