2. Gene
  3. Ghrh - growth hormone releasing hormone Gene

Ghrh - growth hormone releasing hormone Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GRF; Ghrf

Gene ID: 14601 | Gene type: protein coding

About Ghrh

Summary

This gene encodes a hormone that has stimulatory effects on pituitary growth hormone synthesis and release, and somatotrope expansion. The encoded preproprotein undergoes proteolytic processing to generate the mature peptide that is secreted by hypothalamus. Mice lacking the encoded protein are deficient in the growth hormone, live longer and exhibit growth retardation, enhanced Insulin sensitivity and increased xenobiotic metabolism. [provided by RefSeq, Jul 2016]

Ghrh Products(2)

mRNA Protein Name
NM_001329683.1 NP_001316612.1 somatoliberin preproprotein
NM_010285.3 NP_034415.1 somatoliberin preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables growth hormone-releasing hormone receptor binding IPI
IPI: Inferred from physical interaction
11773624 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10537133 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adenohypophysis development IMP
IMP: Inferred from mutant phenotype
15985453 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
10537133 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
1334535 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11773624 MGI
acts upstream of or within growth hormone secretion IDA
IDA: Inferred from direct assay
15070777 MGI
acts upstream of or within growth hormone secretion IMP
IMP: Inferred from mutant phenotype
9348175 MGI
acts upstream of hormone secretion IMP
IMP: Inferred from mutant phenotype
15985453 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11773624 MGI
acts upstream of or within positive regulation of hormone secretion IMP
IMP: Inferred from mutant phenotype
9348175 MGI
acts upstream of or within positive regulation of multicellular organism growth IGI
IGI: Inferred from genetic interaction
16246898 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
15985453 MGI
acts upstream of or within response to food IDA
IDA: Inferred from direct assay
16513828 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
7867561 MGI
located in terminal bouton IDA
IDA: Inferred from direct assay
7694848 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

somatoliberin

growth hormone-releasing factor

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3304 MR 409 Activator 99.51% Unkown
HY-P0089A Human growth hormone-releasing factor TFA 99.66% Unkown
HY-P3397A JV-1-36 acetate Antagonist 99.27% Unkown
HY-P0089 Human growth hormone-releasing factor / Unkown
HY-P3397 JV-1-36 Antagonist / Unkown
HY-P3594 [His1,Nle27] GHRF (1-32), amide, human / Unkown
HY-P3595 GHRF, porcine / Unkown
HY-RS05413 GHRH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16752 Ghrh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23191 Ghrh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ghrh NCBI NCBI:2691