B4galt1 - UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 Gene

Mus musculus

Also known as GalT; Ggtb; Ggtb2; b4Gal-T1; B-1,4-GalT; B-1,4-GalT1; beta4Gal-T1; beta-1,4-GalT; beta-1,4-GalT1

Gene ID: 14595 | Gene type: protein coding

About B4galt1

Summary

This gene encodes two distinct enzyme isoforms, a long membrane-bound form and a short soluble form. These alternate isoforms are thought to be produced through alternative nested transcription initiation and different in-frame start codon usage. These Enzymes catalyze the transfer of galactose to acceptor sugars, such as N-acetylglucosamine and glucose. The long form of this enzyme is localized to the trans-Golgi membrane and is involved in glycoconjugate biosynthesis. The short form functions in lactose biosynthesis though formation of a heterodimer with alpha-lactalbumin. [provided by RefSeq, Nov 2012]

B4galt1 Products(4)

mRNA	Protein	Name
NM_001378519.2	NP_001365448.1	beta-1,4-galactosyltransferase 1 isoform 2
NM_022305.6	NP_071641.1	beta-1,4-galactosyltransferase 1 isoform 1
NM_001378519.2	NP_001365448.1	beta-1,4-galactosyltransferase 1 isoform 2
NM_022305.6	NP_071641.1	beta-1,4-galactosyltransferase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IDA IDA: Inferred from direct assay	9813328	MGI
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IMP IMP: Inferred from mutant phenotype	9013935	MGI
enables galactosyltransferase activity	IDA IDA: Inferred from direct assay	7641815	MGI
enables lactose synthase activity	IMP IMP: Inferred from mutant phenotype	9155011	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8089187	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within acute inflammatory response	IMP IMP: Inferred from mutant phenotype	12714507	MGI
acts upstream of or within angiogenesis involved in wound healing	IMP IMP: Inferred from mutant phenotype	15039218	MGI
acts upstream of or within binding of sperm to zona pellucida	IMP IMP: Inferred from mutant phenotype	9374408	MGI
acts upstream of or within binding of sperm to zona pellucida	IPI IPI: Inferred from physical interaction	8089187	MGI
acts upstream of or within cell adhesion	IGI IGI: Inferred from genetic interaction	12714507	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9155011	MGI
acts upstream of or within development of secondary sexual characteristics	IMP IMP: Inferred from mutant phenotype	11900463	MGI
acts upstream of or within epithelial cell development	IMP IMP: Inferred from mutant phenotype	9155011	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	9155011	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	11900463	MGI
acts upstream of or within galactose metabolic process	IDA IDA: Inferred from direct assay	9813328	MGI
acts upstream of or within glycoprotein biosynthetic process	IMP IMP: Inferred from mutant phenotype	10381349	MGI
acts upstream of or within lactose biosynthetic process	IMP IMP: Inferred from mutant phenotype	9155011	MGI
involved in lactose biosynthetic process	IMP IMP: Inferred from mutant phenotype	9155011	MGI
acts upstream of or within macrophage migration	IMP IMP: Inferred from mutant phenotype	15039218	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	9155011	MGI
acts upstream of or within oligosaccharide biosynthetic process	IDA IDA: Inferred from direct assay	9813328	MGI
acts upstream of or within penetration of zona pellucida	IMP IMP: Inferred from mutant phenotype	9374408	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15282149	MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in wound healing	IMP IMP: Inferred from mutant phenotype	15039218	MGI
acts upstream of or within protein glycosylation	IMP IMP: Inferred from mutant phenotype	9155011	MGI
acts upstream of or within regulation of acrosome reaction	IMP IMP: Inferred from mutant phenotype	9374408	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	15039218	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	2503706	MGI
located in cell surface	IDA IDA: Inferred from direct assay	9374408	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	2503706	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	11485999	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beta-1,4-galactosyltransferase 1

N-acetyllactosamine synthase	UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
b1,4-Galactosyltransferase I	beta-1,4-GalTase 1
beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase	beta-N-acetylglucosaminylglycopep

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70289	Bovin beta-1,4-galactosyltransferase 1 (Y289L)		/	Unkown
HY-E70285	beta-1,4-Galactosyltransferase 1 (Y285L)		/	Unkown
HY-E70046	β-1,4-Galactosyltransferase, neisseria meningitides		90.00%	Unkown
HY-RS01319	B4GALT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18013	B4galt1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24486	B4galt1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	B4galt1	NCBI	NCBI:2683

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