Gdf3 - growth differentiation factor 3 Gene

Mus musculus

Also known as Vgr2; Gdf-3; Vgr-2; ecat9

Gene ID: 14562 | Gene type: protein coding

About Gdf3

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is important in embryogenesis and likely plays a role ocular and skeletal development. Mice lacking a functional copy of this gene exhibit defects in early embryonic development resulting in embryonic lethality. [provided by RefSeq, Aug 2016]

Gdf3 Products(1)

mRNA	Protein	Name
NM_008108.5	NP_032134.2	growth/differentiation factor 3 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16368929	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within endoderm development	IGI IGI: Inferred from genetic interaction	17936261	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	16368929	MGI
acts upstream of or within formation of anatomical boundary	IMP IMP: Inferred from mutant phenotype	16368929	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	17936261	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16368929	MGI
acts upstream of or within mesoderm development	IGI IGI: Inferred from genetic interaction	17936261	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	16368929	MGI
acts upstream of or within negative regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	23844157	MGI
acts upstream of or within notochord development	IMP IMP: Inferred from mutant phenotype	16368929	MGI
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	22223106	MGI
acts upstream of or within primitive streak formation	IMP IMP: Inferred from mutant phenotype	16368929	MGI
acts upstream of or within response to dietary excess	IMP IMP: Inferred from mutant phenotype	18480259	MGI
acts upstream of or within signal transduction	IMP IMP: Inferred from mutant phenotype	17936261	MGI
acts upstream of or within somite rostral/caudal axis specification	IMP IMP: Inferred from mutant phenotype	16368929	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth/differentiation factor 3

VG-1-related protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05354	GDF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20739	Gdf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27251	Gdf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gdf3	NCBI	NCBI:9573

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