Nr6a1 - nuclear receptor subfamily 6, group A, member 1 Gene

Mus musculus

Also known as RTR; Gcnf; NCNF; 1700113M01Rik

Gene ID: 14536 | Gene type: protein coding

About Nr6a1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within gamete generation and negative regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; embryo ectoderm; genitourinary system; nervous system; and retina. Orthologous to human NR6A1 (nuclear receptor subfamily 6 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr6a1 Products(3)

mRNA	Protein	Name
NM_001159548.1	NP_001153020.1	nuclear receptor subfamily 6 group A member 1 isoform 2
NM_001159549.1	NP_001153021.1	nuclear receptor subfamily 6 group A member 1 isoform 3
NM_010264.4	NP_034394.1	nuclear receptor subfamily 6 group A member 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9099702	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	9099702	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11702949	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	9099702	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11702949	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	7854358	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7854358	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in gamete generation	IEP IEP: Inferred from expression pattern	7835709	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11702949	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12381721	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9099702	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	16166633	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor subfamily 6 group A member 1

germ cell nuclear factor	mGCNF
retinoid receptor-related testis-specific receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09555	NR6A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22688	Nr6a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr6a1	NCBI	NCBI:2649

Name
Email *

	Sorry, but the email address you supplied was invalid.