Gata6 - GATA binding protein 6 Gene

Mus musculus

Also known as GATA-6

Gene ID: 14465 | Gene type: protein coding

About Gata6

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in gene expression; heart contraction; and sinoatrial node development. Acts upstream of or within several processes, including animal organ development; cardiac muscle hypertrophy in response to stress; and endodermal cell fate determination. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and heart. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to human GATA6 (GATA binding protein 6). [provided by Alliance of Genome Resources, Apr 2022]

Gata6 Products(1)

mRNA	Protein	Name
NM_010258.3	NP_034388.2	transcription factor GATA-6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11733512	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11914369	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8660897	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15987774	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16293227	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16199866	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11724781	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11914369	MGI
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	11724781	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	16887115	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within animal organ formation	IMP IMP: Inferred from mutant phenotype	16887115	MGI
acts upstream of or within cardiac muscle cell differentiation	IGI IGI: Inferred from genetic interaction	18400219	MGI
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	18400219	MGI
acts upstream of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	19084512	MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	20705924	MGI
acts upstream of or within cardiac muscle tissue development	IGI IGI: Inferred from genetic interaction	20705924	MGI
acts upstream of or within cellular response to BMP stimulus	IDA IDA: Inferred from direct assay	20501701	MGI
acts upstream of or within cellular response to gonadotropin stimulus	IDA IDA: Inferred from direct assay	9231805	MGI
acts upstream of or within club cell differentiation	IGI IGI: Inferred from genetic interaction	17164424	MGI
acts upstream of or within endodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	9832509	MGI
acts upstream of or within endodermal cell fate determination	IDA IDA: Inferred from direct assay	20308546	MGI
acts upstream of or within epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16887115	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	33443158	MGI
involved in heart contraction	IMP IMP: Inferred from mutant phenotype	33443158	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9832509	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	15767668	MGI
acts upstream of or within lung saccule development	IGI IGI: Inferred from genetic interaction	17164424	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	16887115	MGI
acts upstream of or within pancreatic A cell differentiation	IMP IMP: Inferred from mutant phenotype	16887115	MGI
acts upstream of or within phospholipid metabolic process	IGI IGI: Inferred from genetic interaction	17164424	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8660897	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	19084512	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8660897	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16510470	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9832509	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	18400219	MGI
acts upstream of or within response to estrogen	IDA IDA: Inferred from direct assay	9231805	MGI
involved in sinoatrial node development	IMP IMP: Inferred from mutant phenotype	33443158	MGI
acts upstream of or within stem cell differentiation	IGI IGI: Inferred from genetic interaction	18400219	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	18400219	MGI
acts upstream of or within tube morphogenesis	IGI IGI: Inferred from genetic interaction	18400219	MGI
acts upstream of or within type B pancreatic cell differentiation	IMP IMP: Inferred from mutant phenotype	16887115	MGI
acts upstream of or within type II pneumocyte differentiation	IGI IGI: Inferred from genetic interaction	17164424	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12130579	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	17164424	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor GATA-6

GATA-binding factor 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05294	GATA6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17911	Gata6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24380	Gata6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gata6	NCBI	NCBI:2627

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