Gas1 - growth arrest specific 1 Gene

Mus musculus

Also known as Gas-1

Gene ID: 14451 | Gene type: protein coding

About Gas1

Summary

Involved in several processes, including negative regulation of cell growth; odontogenesis; and regulation of smoothened signaling pathway. Acts upstream of or within several processes, including nervous system development; regulation of smoothened signaling pathway; and sensory organ development. Located in plasma membrane. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human GAS1 (growth arrest specific 1). [provided by Alliance of Genome Resources, Apr 2022]

Gas1 Products(1)

mRNA	Protein	Name
NM_008086.3	NP_032112.1	growth arrest-specific protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables oxysterol binding	IMP IMP: Inferred from mutant phenotype	34799735	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11572986	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	11456442	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	17504941	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	17525797	MGI
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	17504941	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	11456441	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11456442	MGI
acts upstream of or within cerebellum morphogenesis	IMP IMP: Inferred from mutant phenotype	11456442	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	11456442	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IGI IGI: Inferred from genetic interaction	17504941	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	17504940	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	17504940	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IGI IGI: Inferred from genetic interaction	17525797	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	17525797	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	17504940	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	17504940	MGI
acts upstream of or within embryonic morphogenesis	IGI IGI: Inferred from genetic interaction	17504941	MGI
acts upstream of or within embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	17504941	MGI
acts upstream of or within embryonic skeletal system development	IGI IGI: Inferred from genetic interaction	17504941	MGI
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	17504941	MGI
acts upstream of or within eye morphogenesis	IMP IMP: Inferred from mutant phenotype	11456441	MGI
acts upstream of or within middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	17525797	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15070677	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11456442	MGI
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	10996316	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11456441	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	15070677	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IDA IDA: Inferred from direct assay	11572986	MGI
involved in odontogenesis	IMP IMP: Inferred from mutant phenotype	19211681	MGI
acts upstream of or within outer ear morphogenesis	IMP IMP: Inferred from mutant phenotype	17525797	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11456442	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17525797	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	17525797	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IDA IDA: Inferred from direct assay	17504940	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	17504940	MGI
acts upstream of or within programmed cell death	IDA IDA: Inferred from direct assay	11906213	MGI
involved in regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19478089	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	17525797	MGI
acts upstream of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	17504940	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	11906213	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10996315	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth arrest-specific protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107199	N-Butylthiophosphoric triamide	Inhibitor	99.76%	Unkown
HY-RS05281	GAS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W016613	Tri(ethylene glycol) monoethyl ether		/	Unkown
HY-RS22178	Gas1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28700	Gas1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gas1	NCBI	NCBI:2619

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