2. Gene
  3. Galt - galactose-1-phosphate uridyl transferase Gene

Galt - galactose-1-phosphate uridyl transferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 14430 | Gene type: protein coding

About Galt

Summary

The protein encoded by this gene is the second enzyme in the Leloir pathway, the metabolic pathway for D-galactose catabolism. It catalyzes the conversion of galactose-1-phosphate and uridine diphosphate-glucose to glucose-1-phosphate and uridine diphosphate galactose. Deficiency of this enzyme causes the genetic metabolic disorder galactosemia. Mice lacking this protein accumulate high levels of galactose and galactose-1 phosphate but are viable and fertile. This protein is negatively regulated through signaling by the polypeptide hormone Prolactin, specifically via the short isoform of the Prolactin receptor and the transcription factor Forkhead box O3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Galt Products(10)

mRNA Protein Name
NM_001302511.2 NP_001289440.1 galactose-1-phosphate uridylyltransferase isoform 2
NM_001369135.1 NP_001356064.1 galactose-1-phosphate uridylyltransferase isoform 3
NM_001369140.1 NP_001356069.1 galactose-1-phosphate uridylyltransferase isoform 4
NM_001369141.1 NP_001356070.1 galactose-1-phosphate uridylyltransferase isoform 4
NM_001369142.1 NP_001356071.1 galactose-1-phosphate uridylyltransferase isoform 4
NM_001369143.1 NP_001356072.1 galactose-1-phosphate uridylyltransferase isoform 2
NM_001369144.1 NP_001356073.1 galactose-1-phosphate uridylyltransferase isoform 2
NM_001369147.1 NP_001356076.1 galactose-1-phosphate uridylyltransferase isoform 2
NM_001395630.1 NP_001382559.1 galactose-1-phosphate uridylyltransferase isoform 5
NM_016658.4 NP_057867.2 galactose-1-phosphate uridylyltransferase isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IDA
IDA: Inferred from direct assay
7323947 MGI
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IMP
IMP: Inferred from mutant phenotype
8902187 MGI
Biological Process GO Annotation Evidence Reference Source
involved in galactose catabolic process via UDP-galactose IMP
IMP: Inferred from mutant phenotype
8902187 MGI
acts upstream of or within galactose metabolic process IMP
IMP: Inferred from mutant phenotype
14741191 MGI
acts upstream of or within glycolytic process from galactose IMP
IMP: Inferred from mutant phenotype
11286504 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

galactose-1-phosphate uridylyltransferase

UDP-glucose--hexose-1-phosphate uridylyltransferase

gal-1-P uridylyltransferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (45)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114364 UDP-Galactose disodium Agonist 99.42% Unkown
HY-E70289 Bovin beta-1,4-galactosyltransferase 1 (Y289L) / Unkown
HY-E70052 alpha-1,3-Galactosyltransferase (a1,3GalT) / Unkown
HY-E70285 beta-1,4-Galactosyltransferase 1 (Y285L) / Unkown
HY-E70047 alpha-1,4-Galactosyltransferase (LgtC) / Unkown
HY-E70046 β-1,4-Galactosyltransferase, neisseria meningitides 90.00% Unkown
HY-E70191 β-1,4-Galactosyltransferase 2 / Unkown
HY-RS01323 B4GALT5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-149125 Globotriaosylceramide (porcine RBC) Inhibitor / Unkown
HY-170663 β-1,4-GALT1-IN-1 Inhibitor / Unkown
HY-E70060 beta-1,4-Galactosyltransferase (LgtE) / Unkown
HY-E70138 β-1,4-Galactosyltransferase 7 / Unkown
HY-P2991 Galactose 1-phosphate uridylyltransferase / Unkown
HY-RS00012 A3GALT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00013 A4GALT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01302 B3GALT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01303 B3GALT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01304 B3GALT4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01305 B3GALT5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01306 B3GALT6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01319 B4GALT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01320 B4GALT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01321 B4GALT3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01322 B4GALT4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01324 B4GALT6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01325 B4GALT7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01707 C1GALT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01708 C1GALT1C1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05267 GALT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18003 A4galt Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18013 B4galt1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18760 Galt Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19086 B4galt5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20622 B3galt5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20623 B4galt3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20624 B4galt4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21231 C1galt1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22079 C1galt1c1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24475 A4galt Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24486 B4galt1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25247 Galt Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25576 B4galt5 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27131 B3galt5 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27132 B4galt3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27133 B4galt4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Galt NCBI NCBI:2592