Xrcc6 - X-ray repair complementing defective repair in Chinese hamster cells 6 Gene

Mus musculus

Also known as Ku70; 70kDa; G22p1

Gene ID: 14375 | Gene type: protein coding

About Xrcc6

Summary

Enables double-stranded DNA binding activity. Involved in positive regulation of lymphocyte differentiation. Acts upstream of or within DNA metabolic process; positive regulation of neurogenesis; and response to ionizing radiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; early conceptus; gonad; liver lobe; and telencephalon ventricular layer. Orthologous to human XRCC6 (X-ray repair cross complementing 6). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc6 Products(3)

mRNA	Protein	Name
NM_001411249.1	NP_001398178.1	X-ray repair cross-complementing protein 6 isoform 1
NM_001411250.1	NP_001398179.1	X-ray repair cross-complementing protein 6 isoform 2
NM_010247.3	NP_034377.2	X-ray repair cross-complementing protein 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	20150414	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12551933	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	15979950	MGI
acts upstream of or within V(D)J recombination	IMP IMP: Inferred from mutant phenotype	10716994	MGI
acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	11751629	MGI
acts upstream of or within double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	11751629	MGI
acts upstream of neurogenesis	IMP IMP: Inferred from mutant phenotype	10716994	MGI
involved in positive regulation of lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	32103174	MGI
acts upstream of or within positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	10716994	MGI
acts upstream of or within response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	15979950	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12604618	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12604618	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

X-ray repair cross-complementing protein 6

5'-dRP/AP lyase Ku70	5'-deoxyribose-5-phosphate lyase Ku70
ATP-dependent DNA helicase 2 subunit 1	ATP-dependent DNA helicase II 70 kDa subunit
CTC box-binding factor 75 kDa subunit	CTC75
CTCBF	DNA repair protein XRCC6
Ku p70	ku autoantigen protei

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15901	XRCC6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19756	Xrcc6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26253	Xrcc6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xrcc6	NCBI	NCBI:2547

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