Fshr - follicle stimulating hormone receptor Gene

Mus musculus

Gene ID: 14309 | Gene type: protein coding

About Fshr

Summary

Enables follicle-stimulating hormone receptor activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; gonad development; and regulation of signal transduction. Located in cell surface. Is expressed in early conceptus and gonad. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Orthologous to human FSHR (follicle stimulating hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Fshr Products(1)

mRNA	Protein	Name
NM_013523.3	NP_038551.3	follicle-stimulating hormone receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables follicle-stimulating hormone receptor activity	IDA IDA: Inferred from direct assay	9206032	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Sertoli cell development	IMP IMP: Inferred from mutant phenotype	14998910	MGI
acts upstream of or within Sertoli cell proliferation	IMP IMP: Inferred from mutant phenotype	11466221	MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	16630814	MGI
acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10330114	MGI
acts upstream of or within basement membrane organization	IMP IMP: Inferred from mutant phenotype	9811848	MGI
acts upstream of or within follicle-stimulating hormone signaling pathway	IDA IDA: Inferred from direct assay	10330114	MGI
acts upstream of or within intracellular water homeostasis	IMP IMP: Inferred from mutant phenotype	14998910	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	14502087	MGI
acts upstream of or within negative regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	11089565	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	12204217	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	9811848	MGI
acts upstream of or within ovulation cycle process	IMP IMP: Inferred from mutant phenotype	11089565	MGI
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10330114	MGI
acts upstream of or within positive regulation of intracellular estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11089565	MGI
acts upstream of or within primary ovarian follicle growth	IMP IMP: Inferred from mutant phenotype	12801993	MGI
acts upstream of or within regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12204217	MGI
acts upstream of or within regulation of acetylcholine metabolic process	IGI IGI: Inferred from genetic interaction	12204217	MGI
acts upstream of or within regulation of chromosome organization	IMP IMP: Inferred from mutant phenotype	14680821	MGI
acts upstream of or within regulation of hormone metabolic process	IMP IMP: Inferred from mutant phenotype	12204217	MGI
acts upstream of or within regulation of intracellular estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18063689	MGI
acts upstream of or within regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	16630814	MGI
acts upstream of or within regulation of platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16344272	MGI
acts upstream of or within regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	12204217	MGI
acts upstream of or within regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	18599597	MGI
acts upstream of or within sperm DNA condensation	IMP IMP: Inferred from mutant phenotype	10775161	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	11466221	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	9811848	MGI
acts upstream of or within uterus development	IMP IMP: Inferred from mutant phenotype	10803590	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	16630814	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

follicle-stimulating hormone receptor

follitropin receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12381	ML224	Antagonist	99.18%	Unkown
HY-P4190	Fsh receptor-binding inhibitor fragment(bi-10)	Antagonist	99.77%	Unkown
HY-P3343A	hFSH-β-(33-53) (TFA)	Agonist	99.81%	Unkown
HY-150210	FSHR agonist 1	Agonist	98.48%	Unkown
HY-164764	ADX61623	Inhibitor	98.84%	Unkown
HY-160856	TOP5300	Agonist	/	Unkown
HY-160857	TOP5668	Agonist	/	Unkown
HY-P10780	RFRP-3 (mouse)		/	Unkown
HY-RS05124	FSHR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16988	Fshr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23431	Fshr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fshr	NCBI	NCBI:2492

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