Fnta - farnesyltransferase, CAAX box, alpha Gene

Mus musculus

Also known as FTA

Gene ID: 14272 | Gene type: protein coding

About Fnta

Summary

Enables acetylcholine receptor regulator activity; Protein Prenyltransferase activity; and receptor tyrosine kinase binding activity. Acts upstream of or within neurotransmitter receptor metabolic process. Predicted to be part of CAAX-protein geranylgeranyltransferase complex; microtubule associated complex; and protein farnesyltransferase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; brain; hemolymphoid system gland; and reproductive system. Orthologous to human FNTA (farnesyltransferase, CAAX box, alpha). [provided by Alliance of Genome Resources, Apr 2022]

Fnta Products(1)

mRNA	Protein	Name
NM_008033.4	NP_032059.1	protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables Rab geranylgeranyltransferase activity	IDA IDA: Inferred from direct assay	14622576	MGI
enables protein farnesyltransferase activity	IDA IDA: Inferred from direct assay	14622576	MGI
enables protein geranylgeranyltransferase activity	IMP IMP: Inferred from mutant phenotype	14622576	MGI
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	14622576	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in enzyme-linked receptor protein signaling pathway	IDA IDA: Inferred from direct assay	18848351	MGI
involved in enzyme-linked receptor protein signaling pathway	IGI IGI: Inferred from genetic interaction	8653787	MGI
involved in enzyme-linked receptor protein signaling pathway	IMP IMP: Inferred from mutant phenotype	14622576	MGI
involved in positive regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	14622576	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IDA IDA: Inferred from direct assay	18848351	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IGI IGI: Inferred from genetic interaction	8653787	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	14622576	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

CAAX farnesyltransferase subunit alpha	FTase-alpha
GGTase-I-alpha	ras proteins prenyltransferase subunit alpha
type I protein geranyl-geranyltransferase subunit alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05025	FNTA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22173	Fnta Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fnta	NCBI	NCBI:2339

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