2. Gene
  3. Fn1 - fibronectin 1 Gene

Fn1 - fibronectin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fn; Fn-1; E330027I09

Gene ID: 14268 | Gene type: protein coding

About Fn1

Summary

Enables peptidase activator activity. Acts upstream of or within several processes, including calcium-independent cell-matrix adhesion; cell-substrate junction assembly; and positive regulation of axon extension. Located in apical plasma membrane and basement membrane. Is expressed in several structures, including alimentary system; cardiovascular system; egg cylinder; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Apr 2022]

Fn1 Products(7)

mRNA Protein Name
NM_001276408.1 NP_001263337.1 fibronectin isoform b precursor
NM_001276409.1 NP_001263338.1 fibronectin isoform c precursor
NM_001276410.1 NP_001263339.1 fibronectin isoform d precursor
NM_001276411.1 NP_001263340.1 fibronectin isoform e precursor
NM_001276412.1 NP_001263341.1 fibronectin isoform f precursor
NM_001276413.1 NP_001263342.1 fibronectin isoform g precursor
NM_010233.2 NP_034363.1 fibronectin isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activator activity IDA
IDA: Inferred from direct assay
16061471 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
36812915 MGI
enables signaling receptor binding IDA
IDA: Inferred from direct assay
34089617 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within calcium-independent cell-matrix adhesion IDA
IDA: Inferred from direct assay
19651211 MGI
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
9441684 MGI
acts upstream of or within cell-matrix adhesion IDA
IDA: Inferred from direct assay
15728191 MGI
acts upstream of or within cell-substrate junction assembly IDA
IDA: Inferred from direct assay
12867986 MGI
involved in negative regulation of monocyte activation IDA
IDA: Inferred from direct assay
34089617 MGI
acts upstream of or within positive regulation of axon extension IDA
IDA: Inferred from direct assay
12879062 MGI
involved in response to muscle activity IDA
IDA: Inferred from direct assay
36812915 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
12847088 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10742111 MGI
located in basement membrane IDA
IDA: Inferred from direct assay
8984825 MGI
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
34368841 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
2209468 MGI
is active in extracellular space IDA
IDA: Inferred from direct assay
36812915 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibronectin

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-138657 NCGC00378430 Inhibitor 99.58% Unkown
HY-RS05013 FN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16767 Fn1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23207 Fn1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fn1 NCBI NCBI:2335