Lpin1 - lipin 1 Gene

Mus musculus

Also known as fld; Lipin1

Gene ID: 14245 | Gene type: protein coding

About Lpin1

Summary

Enables several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate Phosphatase activity. Involved in several processes, including mitochondrial fission; positive regulation of cold-induced thermogenesis; and triglyceride mobilization. Acts upstream of or within several processes, including actin Cytoskeleton reorganization; positive regulation of histone deacetylation; and ruffle organization. Located in endoplasmic reticulum; mitochondrial outer membrane; and nuclear membrane. Part of transcription regulator complex. Is expressed in liver; nervous system; olfactory epithelium; and tooth. Used to study lipodystrophy. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Apr 2022]

Lpin1 Products(4)

mRNA	Protein	Name
NM_001130412.1	NP_001123884.1	phosphatidate phosphatase LPIN1 isoform a
NM_001355598.1	NP_001342527.1	phosphatidate phosphatase LPIN1 isoform b
NM_015763.4	NP_056578.2	phosphatidate phosphatase LPIN1 isoform b
NM_172950.3	NP_766538.2	phosphatidate phosphatase LPIN1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	20385772	MGI
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	20385772	MGI
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	16950137	MGI
enables phosphatidate phosphatase activity	IDA IDA: Inferred from direct assay	17158099	MGI
enables phosphatidate phosphatase activity	IGI IGI: Inferred from genetic interaction	24133206	MGI
enables phosphatidate phosphatase activity	IMP IMP: Inferred from mutant phenotype	24133206	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16950137	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16950137	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	10438476	MGI
acts upstream of or within cellular lipid metabolic process	IMP IMP: Inferred from mutant phenotype	22337502	MGI
acts upstream of or within cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	10438476	MGI
involved in fatty acid catabolic process	IDA IDA: Inferred from direct assay	16950137	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	22337502	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	2722772	MGI
involved in mitochondrial fission	IDA IDA: Inferred from direct assay	21397848	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20385772	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	23028044	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16950137	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20385772	MGI
acts upstream of or within regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	11138012	MGI
acts upstream of or within ruffle organization	IMP IMP: Inferred from mutant phenotype	10438476	MGI
involved in triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	24133206	MGI
involved in triglyceride mobilization	IDA IDA: Inferred from direct assay	16950137	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19753306	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	26475860	MGI
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17105729	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	21397848	MGI
located in nuclear membrane	IDA IDA: Inferred from direct assay	22134922	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11138012	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	20385772	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphatidate phosphatase LPIN1

fatty liver dystrophy protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07769	LPIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19455	Lpin1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25948	Lpin1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lpin1	NCBI	NCBI:23175

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