2. Gene
  3. Fga - fibrinogen alpha chain Gene

Fga - fibrinogen alpha chain Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fib

Gene ID: 14161 | Gene type: protein coding

About Fga

Summary

This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by Thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and soft tissues around joints immediately after birth, and are predisposed to spontaneous fatal abdominal hemorrhage as they grow. Pregnant mice lacking the encoded protein succumb to uterine bleeding during gestation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]

Fga Products(2)

mRNA Protein Name
NM_001111048.2 NP_001104518.1 fibrinogen alpha chain isoform 1 preproprotein
NM_010196.4 NP_034326.1 fibrinogen alpha chain isoform 2 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
10930441 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell cortex IDA
IDA: Inferred from direct assay
15914557 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16452087 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16452087 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibrinogen alpha chain

fibrinogen, A alpha polypeptide

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-161244 FGA145 Inhibitor / Unkown
HY-161245 FGA146 Inhibitor / Unkown
HY-172977 FGA139 Inhibitor / Unkown
HY-176305S Neurofilament, U-15N / Unkown
HY-NP018 Bovine fibrinogen (from plasma) Activator / Unkown
HY-RS04878 FGA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17677 Fga Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24138 Fga Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fga NCBI NCBI:2243