2. Gene
  3. Fen1 - flap structure specific endonuclease 1 Gene

Fen1 - flap structure specific endonuclease 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as FEN-1

Gene ID: 14156 | Gene type: protein coding

About Fen1

Summary

Enables DNA binding activity; metal ion binding activity; and nuclease activity. Acts upstream of or within DNA repair and DNA replication. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human FEN1 (FLAP structure-specific Endonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

Fen1 Products(4)

mRNA Protein Name
NM_001271614.2 NP_001258543.1 flap endonuclease 1
NM_001271615.3 NP_001258544.1 flap endonuclease 1
NM_001410282.1 NP_001397211.1 flap endonuclease 1
NM_007999.6 NP_032025.2 flap endonuclease 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
12162748 MGI
enables exonuclease activity IDA
IDA: Inferred from direct assay
12162748 MGI
enables flap endonuclease activity IDA
IDA: Inferred from direct assay
12162748 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
12162748 MGI
enables manganese ion binding IDA
IDA: Inferred from direct assay
12162748 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
12861020 MGI
acts upstream of or within DNA replication IMP
IMP: Inferred from mutant phenotype
12861020 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

flap endonuclease 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123834 FEN1-IN-1 99.85% Unkown
HY-136485 FEN1-IN-4 Inhibitor 99.86% Unkown
HY-145758 FEN1-IN-SC13 Inhibitor 98.21% Unkown
HY-122695 FEN1-IN-2 Inhibitor 99.94% Unkown
HY-153790 FEN1-IN-5 Inhibitor 99.79% Unkown
HY-136484 FEN1-IN-3 Inhibitor 98.06% Unkown
HY-153792 FEN1-IN-7 Inhibitor / Unkown
HY-153791 FEN1-IN-6 Inhibitor / Unkown
HY-170845 MU1409 Inhibitor 98.52% Unkown
HY-RS04861 FEN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16635 Fen1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23070 Fen1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fen1 NCBI NCBI:2237