2. Gene
  3. Pofut1 - protein O-fucosyltransferase 1 Gene

Pofut1 - protein O-fucosyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as O-FucT-1

Gene ID: 140484 | Gene type: protein coding

About Pofut1

Summary

Predicted to enable peptide-O-fucosyltransferase activity. Involved in Notch signaling pathway. Acts upstream of or within circulatory system development; nervous system development; and somitogenesis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in brain; embryo; skeletal muscle tissue; and skeletal musculature. Human ortholog(s) of this gene implicated in Dowling-Degos disease. Orthologous to human POFUT1 (protein O-fucosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pofut1 Products(1)

mRNA Protein Name
NM_080463.4 NP_536711.3 GDP-fucose protein O-fucosyltransferase 1 precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
12697902 MGI
involved in Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
19161597 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
12697902 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
12697902 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
12697902 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
12697902 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GDP-fucose protein O-fucosyltransferase 1

peptide-O-fucosyltransferase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-E70160 Protein O-Fucosyltransferase 1 / Unkown
HY-RS10811 POFUT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20191 Pofut1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26695 Pofut1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pofut1 NCBI NCBI:23509