Eya1 - EYA transcriptional coactivator and phosphatase 1 Gene

Mus musculus

Also known as bor

Gene ID: 14048 | Gene type: protein coding

About Eya1

Summary

Enables RNA binding activity and protein tyrosine Phosphatase activity. Involved in mesodermal cell fate specification; positive regulation of transcription, DNA-templated; and protein sumoylation. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in cytoplasm and nucleus. Part of protein-DNA complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study branchiootorenal syndrome. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and branchiootorenal syndrome 1. Orthologous to human EYA1 (EYA transcriptional coactivator and Phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Eya1 Products(7)

mRNA	Protein	Name
NM_001252192.2	NP_001239121.1	eyes absent homolog 1 isoform 2
NM_001310459.2	NP_001297388.1	eyes absent homolog 1 isoform 3
NM_001402659.1	NP_001389588.1	eyes absent homolog 1 isoform 4
NM_001402660.1	NP_001389589.1	eyes absent homolog 1 isoform 5
NM_001402661.1	NP_001389590.1	eyes absent homolog 1 isoform 6
NM_001402662.1	NP_001389591.1	eyes absent homolog 1 isoform 7
NM_010164.3	NP_034294.2	eyes absent homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	21936910	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11734542	MGI
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	14628052	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anatomical structure development	IGI IGI: Inferred from genetic interaction	16530750	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	12070080	MGI
acts upstream of or within aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	21364285	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	12783782	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	15817220	MGI
acts upstream of or within cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	10072433	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	10471511	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16916509	MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	15817220	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	16916509	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	10471511	MGI
involved in mesodermal cell fate specification	IDA IDA: Inferred from direct assay	17785448	MGI
acts upstream of or within metanephros development	IMP IMP: Inferred from mutant phenotype	10072433	MGI
acts upstream of or within middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	10471511	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	15817220	MGI
acts upstream of or within neuron fate specification	IGI IGI: Inferred from genetic interaction	22513373	MGI
acts upstream of or within otic vesicle development	IGI IGI: Inferred from genetic interaction	22513373	MGI
acts upstream of or within otic vesicle morphogenesis	IMP IMP: Inferred from mutant phenotype	16916509	MGI
acts upstream of or within outer ear morphogenesis	IMP IMP: Inferred from mutant phenotype	10471511	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	21364285	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	16530750	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	16916509	MGI
acts upstream of or within pharyngeal system development	IMP IMP: Inferred from mutant phenotype	21364285	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17785448	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16916509	MGI
acts upstream of or within positive regulation of secondary heart field cardioblast proliferation	IGI IGI: Inferred from genetic interaction	21364285	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21364285	MGI
acts upstream of or within protein dephosphorylation	IDA IDA: Inferred from direct assay	14628052	MGI
involved in protein sumoylation	IDA IDA: Inferred from direct assay	16990542	MGI
acts upstream of or within regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	22513373	MGI
acts upstream of or within regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15496442	MGI
acts upstream of or within semicircular canal morphogenesis	IMP IMP: Inferred from mutant phenotype	10072433	MGI
acts upstream of or within striated muscle tissue development	IGI IGI: Inferred from genetic interaction	17098221	MGI
acts upstream of or within ureteric bud development	IGI IGI: Inferred from genetic interaction	16018995	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16024294	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16024294	MGI
part of protein-DNA complex	IDA IDA: Inferred from direct assay	17785448	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17785448	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eyes absent homolog 1

eyes absent 1 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158059	DS-1-38	Inhibitor	99.60%	Unkown
HY-RS04611	EYA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22165	Eya1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eya1	NCBI	NCBI:2138

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