Etv2 - ets variant 2 Gene

Mus musculus

Also known as Etsrp71

Gene ID: 14008 | Gene type: protein coding

About Etv2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of endothelial cell differentiation; and positive regulation of mesoderm development. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system and hemolymphoid system. Orthologous to human ETV2 (ETS variant transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Etv2 Products(1)

mRNA	Protein	Name
NM_007959.2	NP_031985.2	ETS translocation variant 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12087183	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	12087183	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12087183	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within Wnt signaling pathway	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within blastocyst development	IMP IMP: Inferred from mutant phenotype	16630543	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	18462699	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	18462699	MGI
acts upstream of or within hemopoiesis	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	18462699	MGI
acts upstream of or within mesoderm formation	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	18462699	MGI
acts upstream of or within positive regulation of endothelial cell differentiation	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18462699	MGI
acts upstream of or within positive regulation of mesoderm development	IDA IDA: Inferred from direct assay	18462699	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12087183	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16630543	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12087183	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ETS translocation variant 2

ets variant gene 2

ets-related protein 71

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04565	ETV2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21336	Etv2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Etv2	NCBI	NCBI:2116

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