Eps15 - epidermal growth factor receptor pathway substrate 15 Gene

Mus musculus

Also known as 2410112D09Rik

Gene ID: 13858 | Gene type: protein coding

About Eps15

Summary

Enables identical protein binding activity. Acts upstream of or within regulation of protein localization. Located in ciliary membrane; clathrin-coated pit; and clathrin-coated vesicle. Part of AP-2 adaptor complex. Is expressed in several structures, including adrenal gland; alimentary system; heart; metanephros; and nervous system. Orthologous to human EPS15 (epidermal growth factor receptor pathway substrate 15). [provided by Alliance of Genome Resources, Apr 2022]

Eps15 Products(2)

mRNA	Protein	Name
NM_001159964.1	NP_001153436.1	epidermal growth factor receptor substrate 15 isoform B
NM_007943.3	NP_031969.1	epidermal growth factor receptor substrate 15 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18154663	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9446614	MGI
enables ubiquitin binding	IDA IDA: Inferred from direct assay	15383614	MGI
enables ubiquitin binding	IMP IMP: Inferred from mutant phenotype	15383614	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	17868307	MGI
involved in ubiquitin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	15383614	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of AP-2 adaptor complex	IDA IDA: Inferred from direct assay	17626015	MGI
located in ciliary membrane	IDA IDA: Inferred from direct assay	20427320	MGI
part of clathrin coat of coated pit	IDA IDA: Inferred from direct assay	18434600	MGI
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	20427320	MGI
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	17626015	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17626015	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

epidermal growth factor receptor substrate 15

epidermal growth factor pathway substrate 15

protein AF-1p

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04452	EPS15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04453	EPS15L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22489	Eps15 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eps15	NCBI	NCBI:2060

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