Epha8 - Eph receptor A8 Gene

Mus musculus

Also known as Eek; Hek3; mKIAA1459

Gene ID: 13842 | Gene type: protein coding

About Epha8

Summary

Enables GPI-linked Ephrin Receptor activity and growth factor binding activity. Involved in several processes, including Ephrin Receptor signaling pathway; neuron development; and positive regulation of phosphatidylinositol 3-kinase activity. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus. Located in neuron projection. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human EphA8 (EPH receptor A8). [provided by Alliance of Genome Resources, Apr 2022]

Epha8 Products(1)

mRNA	Protein	Name
NM_007939.2	NP_031965.2	ephrin type-A receptor 8 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GPI-linked ephrin receptor activity	IDA IDA: Inferred from direct assay	9053851	MGI
enables ephrin receptor activity	IDA IDA: Inferred from direct assay	11416136	MGI
enables growth factor binding	IPI IPI: Inferred from physical interaction	22568954	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9053851	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	9214628	MGI
acts upstream of or within cellular response to follicle-stimulating hormone stimulus	IDA IDA: Inferred from direct assay	23242526	MGI
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	9053851	MGI
involved in neuron projection development	IDA IDA: Inferred from direct assay	15782114	MGI
involved in neuron remodeling	IDA IDA: Inferred from direct assay	17875921	MGI
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15782114	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	11416136	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10498895	MGI
involved in regulation of cell adhesion	IDA IDA: Inferred from direct assay	10498895	MGI
involved in regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	11416136	MGI
involved in substrate-dependent cell migration	IDA IDA: Inferred from direct assay	17875921	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuron projection	IDA IDA: Inferred from direct assay	17875921	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9053851	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ephrin type-A receptor 8

EPH- and ELK-related kinase	Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase)
tyrosine-protein kinase receptor EEK

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146375	UniPR505	Antagonist	/	Unkown
HY-RS04432	EPHA8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20398	Epha8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26907	Epha8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epha8	NCBI	NCBI:2046

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