Epas1 - endothelial PAS domain protein 1 Gene

Mus musculus

Also known as HLF; HRF; MOP2; HIF2A; bHLHe73; HIF-2alpha

Gene ID: 13819 | Gene type: protein coding

About Epas1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in mRNA transcription by RNA polymerase II; myoblast fate commitment; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including animal organ development; regulation of transcription by RNA polymerase II; and surfactant homeostasis. Located in cytoplasm and nuclear speck. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and respiratory system. Used to study newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Epas1 Products(1)

mRNA	Protein	Name
NM_010137.3	NP_034267.3	endothelial PAS domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	17404621	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21856340	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12464608	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	9113979	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12464608	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9113979	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	26245371	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	26245371	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	12464608	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	12053176	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	10880563	MGI
acts upstream of or within cell differentiation	IGI IGI: Inferred from genetic interaction	16287860	MGI
acts upstream of or within embryonic placenta development	IGI IGI: Inferred from genetic interaction	16287860	MGI
acts upstream of or within epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	12053176	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17284606	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	25414188	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	18635823	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	12750163	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	12053176	MGI
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18635823	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	14608355	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IGI IGI: Inferred from genetic interaction	22128145	MGI
involved in myoblast fate commitment	IMP IMP: Inferred from mutant phenotype	21106753	MGI
acts upstream of or within norepinephrine metabolic process	IMP IMP: Inferred from mutant phenotype	9808618	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	26572826	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12464608	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9113979	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17404621	MGI
acts upstream of or within regulation of heart rate	IMP IMP: Inferred from mutant phenotype	9808618	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14608355	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	12832481	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17284606	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	15626745	MGI
acts upstream of or within response to oxidative stress	IGI IGI: Inferred from genetic interaction	17322295	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	14608355	MGI
acts upstream of or within surfactant homeostasis	IMP IMP: Inferred from mutant phenotype	12053176	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17404621	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	15728559	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12832481	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	21546903	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12464608	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12464608	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

endothelial PAS domain-containing protein 1

EPAS-1	HIF-1-alpha-like factor
HIF-2-alpha	HIF-related factor
HIF1 alpha-like factor	HIF1alpha-like factor
HIF2-alpha	HLF (HIF1alpha-like factor)
Hif like protein	hypoxia inducible transcription factor 2alpha
hypoxia-inducible factor 2-alpha	mH

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04409	EPAS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B0660S1	Eicosapentaenoic acid 1,2,3,4,5-13C5	Activator	/	Unkown
HY-RS18998	Epas1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25487	Epas1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epas1	NCBI	NCBI:2034

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