Elk1 - ELK1, member of ETS oncogene family Gene

Mus musculus

Also known as Elk-1

Gene ID: 13712 | Gene type: protein coding

About Elk1

Summary

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-Fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene may produce multiple isoforms by the use of alternative translational start codons. [provided by RefSeq, Mar 2012]

Elk1 Products(1)

mRNA	Protein	Name
NM_007922.5	NP_031948.4	ETS domain-containing protein Elk-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12473665	MGI
enables mediator complex binding	IPI IPI: Inferred from physical interaction	7738173	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16549787	MGI
enables transcription regulator activator activity	IMP IMP: Inferred from mutant phenotype	7738173	MGI
enables transcription regulator inhibitor activity	IMP IMP: Inferred from mutant phenotype	7738173	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	31877385	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	31877385	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	31877385	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15896720	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12473665	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ETS domain-containing protein Elk-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152860	Darizmetinib		99.94%	Unkown
HY-135699	TD52		≥95.0%	Unkown
HY-113592	ERK-IN-4	Inhibitor	99.61%	Unkown
HY-RS04305	ELK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-135699A	TD52 dihydrochloride		99.90%	Unkown
HY-111000	BNC-1		/	Unkown
HY-163323	AKR1C3-IN-12	Inhibitor	/	Unkown
HY-122241	MT477	Inhibitor	/	Unkown
HY-RS17329	Elk1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23784	Elk1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Elk1	NCBI	NCBI:2002

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