Eif4g2 - eukaryotic translation initiation factor 4, gamma 2 Gene

Mus musculus

Also known as p97; Nat1; DAP-5; Natm1; E130105L11Rik

Gene ID: 13690 | Gene type: protein coding

About Eif4g2

Summary

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the Apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Eif4g2 Products(2)

mRNA	Protein	Name
NM_001040131.2	NP_001035221.1	eukaryotic translation initiation factor 4 gamma 2 isoform 2
NM_013507.3	NP_038535.2	eukaryotic translation initiation factor 4 gamma 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12482958	MGI
enables translation initiation factor activity	IDA IDA: Inferred from direct assay	9030685	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of translational initiation	IDA IDA: Inferred from direct assay	9030685	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12388085	MGI
is active in postsynaptic density	EXP EXP: Inferred from Experiment	25211037	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	25211037	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4 gamma 2

eIF-4-gamma 2	eIF-4G 2
eIF4G 2	novel APOBEC-1 target 1
translation repressor Nat1

Eif4g2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Eif4g2	Q62448	Pdcd4	Mus musculus	Q61823	Pull Down	12482958

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04282	EIF4G2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif4g2	NCBI	NCBI:1982

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