Eif4ebp2 - eukaryotic translation initiation factor 4E binding protein 2 Gene

Mus musculus

Also known as 4E-BP2; PHAS-II; 2810011I19Rik

Gene ID: 13688 | Gene type: protein coding

About Eif4ebp2

Summary

Enables eukaryotic initiation factor 4E binding activity and translation repressor activity. Involved in several processes, including memory; negative regulation of translational initiation; and social behavior. Acts upstream of or within TOR signaling and Insulin Receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in heart; liver; and lung. Used to study autism spectrum disorder. Orthologous to human EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Eif4ebp2 Products(1)

mRNA	Protein	Name
NM_010124.2	NP_034254.1	eukaryotic translation initiation factor 4E-binding protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables eukaryotic initiation factor 4E binding	IMP IMP: Inferred from mutant phenotype	20347422	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8939971	MGI
enables translation repressor activity	IMP IMP: Inferred from mutant phenotype	16237163	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within TOR signaling	IDA IDA: Inferred from direct assay	8939971	MGI
involved in TOR signaling	IMP IMP: Inferred from mutant phenotype	20347422	MGI
acts upstream of or within insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	8939971	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	16237163	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	20347422	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	23172145	MGI
involved in negative regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	16237163	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	16237163	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	17029989	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4E-binding protein 2

eIF4E-binding protein 2

phosphorylated heat- and acid-stable protein regulated by insulin 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04278	EIF4EBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20664	Eif4ebp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27175	Eif4ebp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif4ebp2	NCBI	NCBI:1979

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