Egr1 - early growth response 1 Gene

Mus musculus

Also known as egr; TIS8; Zenk; Egr-1; NGFIA; Zfp-6; ETR103; Krox-1; Krox24; NGF1-A; NGFI-A; Zif268; Krox-24; A530045N19Rik

Gene ID: 13653 | Gene type: protein coding

About Egr1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to gamma radiation; regulation of gene expression; and regulation of hormone biosynthetic process. Acts upstream of or within several processes, including BMP signaling pathway; regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2022]

Egr1 Products(1)

mRNA	Protein	Name
NM_007913.5	NP_031939.1	early growth response protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	18323529	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20018936	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	8336701	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12689920	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20018936	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15958557	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	8336701	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	31467272	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18281035	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	8769660	MGI
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	12165491	MGI
involved in cellular response to gamma radiation	IMP IMP: Inferred from mutant phenotype	19057511	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26471974	MGI
involved in circadian temperature homeostasis	IMP IMP: Inferred from mutant phenotype	29138967	MGI
involved in estrous cycle	IMP IMP: Inferred from mutant phenotype	8703054	MGI
involved in locomotor rhythm	IMP IMP: Inferred from mutant phenotype	29138967	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18281035	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16033766	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7720589	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17202132	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	26471974	MGI
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	11100120	MGI
involved in positive regulation of gene expression via chromosomal CpG island demethylation	IGI IGI: Inferred from genetic interaction	31467272	MGI
involved in positive regulation of hormone biosynthetic process	IMP IMP: Inferred from mutant phenotype	8703054	MGI
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	11100120	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20018936	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8336701	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12165491	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23277542	MGI
involved in regulation of progesterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	8703054	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18323529	MGI
involved in response to glucose	IDA IDA: Inferred from direct assay	12689920	MGI
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	11100120	MGI
involved in response to insulin	IDA IDA: Inferred from direct assay	12689920	MGI
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	11100120	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8668170	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

early growth response protein 1

Krox-24 nuclear protein	nerve growth factor-induced protein A
transcription factor Zif268	zinc finger protein Krox-24

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157549	Brivoligide		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163731	EGR-1-IN-1	Inhibitor	98.11%	Unkown
HY-116818	Crebinostat	Inhibitor	99.79%	Unkown
HY-146411	microRNA-21-IN-1		98.03%	Unkown
HY-RS04215	EGR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-125980	LX-3	Inhibitor	98.08%	Unkown
HY-169118	EGR-1-IN-2	Inhibitor	99.61%	Unkown
HY-131721	14,15-EET-SI	Activator	/	Unkown
HY-170415	EGR-1-IN-3	Inhibitor	/	Unkown
HY-RS16606	Egr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23040	Egr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Egr1	NCBI	NCBI:1958

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