2. Gene
  3. E2f1 - E2F transcription factor 1 Gene

E2f1 - E2F transcription factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor

Gene ID: 13555 | Gene type: protein coding

About E2f1

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; and transcription, DNA-templated. Acts upstream of or within several processes, including anoikis; intrinsic apoptotic signaling pathway by p53 class mediator; and lens fiber cell apoptotic process. Located in chromatin; cytoplasm; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

E2f1 Products(2)

mRNA Protein Name
NM_001291105.1 NP_001278034.1 transcription factor E2F1 isoform b precursor
NM_007891.5 NP_031917.1 transcription factor E2F1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity IDA
IDA: Inferred from direct assay
35263589 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10779331 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10597240 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11672531 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
24014029 MGI
Biological Process GO Annotation Evidence Reference Source
involved in DNA-templated transcription IDA
IDA: Inferred from direct assay
11672531 MGI
acts upstream of or within anoikis IDA
IDA: Inferred from direct assay
14667810 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
24726645 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
15525772 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IDA
IDA: Inferred from direct assay
11095619 MGI
acts upstream of or within lens fiber cell apoptotic process IDA
IDA: Inferred from direct assay
11095619 MGI
involved in negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
11672531 MGI
involved in negative regulation of fat cell proliferation IMP
IMP: Inferred from mutant phenotype
20176812 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11331592 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11004506 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
7797074 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11071387 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
11095619 MGI
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
35263589 MGI
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
12007404 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
8918469 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
10082561 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8918469 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
10082561 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor E2F1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-117857 MRT00033659 99.77% Unkown
HY-162384 EPIC-0628 Inhibitor 98.93% Unkown
HY-RS04110 E2F1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17052 E2f1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23496 E2f1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens E2f1 NCBI NCBI:1869