Dvl1 - dishevelled segment polarity protein 1 Gene

Mus musculus

Also known as Dvl; mKIAA4029

Gene ID: 13542 | Gene type: protein coding

About Dvl1

Summary

The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 Amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Dvl1 Products(2)

mRNA	Protein	Name
NM_001356381.1	NP_001343310.1	segment polarity protein dishevelled homolog DVL-1 isoform 2
NM_010091.5	NP_034221.3	segment polarity protein dishevelled homolog DVL-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IDA IDA: Inferred from direct assay	21880741	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11113207	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22899650	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IDA IDA: Inferred from direct assay	14966280	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IGI IGI: Inferred from genetic interaction	14966280	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	16116426	MGI
acts upstream of or within axon extension	IDA IDA: Inferred from direct assay	18716223	MGI
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	18716223	MGI
acts upstream of or within axonogenesis	IDA IDA: Inferred from direct assay	14734535	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	14648878	MGI
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	10409711	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	11742004	MGI
acts upstream of or within cochlea morphogenesis	IGI IGI: Inferred from genetic interaction	16116426	MGI
acts upstream of or within collateral sprouting	IDA IDA: Inferred from direct assay	18716223	MGI
acts upstream of or within convergent extension involved in neural plate elongation	IGI IGI: Inferred from genetic interaction	16571627	MGI
acts upstream of or within convergent extension involved in organogenesis	IGI IGI: Inferred from genetic interaction	16116426	MGI
acts upstream of or within convergent extension involved in organogenesis	IMP IMP: Inferred from mutant phenotype	16116426	MGI
acts upstream of or within cytoplasmic microtubule organization	IDA IDA: Inferred from direct assay	14648878	MGI
acts upstream of or within cytoplasmic microtubule organization	IGI IGI: Inferred from genetic interaction	14648878	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	15608632	MGI
involved in heart looping	IGI IGI: Inferred from genetic interaction	22841628	MGI
acts upstream of or within negative regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	9271238	MGI
acts upstream of or within neuromuscular junction development	IGI IGI: Inferred from genetic interaction	12165471	MGI
acts upstream of or within neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	16818724	MGI
involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	22841628	MGI
acts upstream of or within positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	15548427	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	24305805	MGI
involved in postsynapse organization	IDA IDA: Inferred from direct assay	21670302	MGI
involved in postsynapse organization	IMP IMP: Inferred from mutant phenotype	21670302	MGI
acts upstream of or within prepulse inhibition	IMP IMP: Inferred from mutant phenotype	9298901	MGI
involved in presynapse assembly	IDA IDA: Inferred from direct assay	16818724	MGI
involved in presynapse assembly	IMP IMP: Inferred from mutant phenotype	16818724	MGI
acts upstream of or within protein localization to microtubule	IGI IGI: Inferred from genetic interaction	18716223	MGI
involved in protein stabilization	IGI IGI: Inferred from genetic interaction	26359454	MGI
acts upstream of or within receptor clustering	IGI IGI: Inferred from genetic interaction	12165471	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	23826333	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	23826333	MGI
acts upstream of or within regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	14734535	MGI
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	26400647	MGI
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	26400647	MGI
acts upstream of or within skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	19020093	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	9298901	MGI
acts upstream of or within synapse organization	IGI IGI: Inferred from genetic interaction	16818724	MGI
acts upstream of or within synapse organization	IMP IMP: Inferred from mutant phenotype	16818724	MGI
acts upstream of positive effect synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	16818724	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	26400647	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	26400647	MGI
part of Wnt signalosome	IDA IDA: Inferred from direct assay	22899650	MGI
located in axon	IDA IDA: Inferred from direct assay	14734535	MGI
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	17005174	MGI
colocalizes with cytoplasm	IDA IDA: Inferred from direct assay	12138115	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	11113207	MGI
is active in cytosol	IDA IDA: Inferred from direct assay	21189423	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21670302	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	21670302	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21670302	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	14734535	MGI
is active in neuronal dense core vesicle	EXP EXP: Inferred from Experiment	21321602	MGI
is active in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	21321602	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12138115	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	21670302	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	21670302	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	16818724	MGI
is active in presynapse	IMP IMP: Inferred from mutant phenotype	16818724	MGI
located in synapse	IDA IDA: Inferred from direct assay	16818724	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

segment polarity protein dishevelled homolog DVL-1

DSH homolog 1	dishevelled, dsh homolog 1
dishevelled-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04076	DVL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20720	Dvl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27232	Dvl1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dvl1	NCBI	NCBI:1855

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