2. Gene
  3. Dpp6 - dipeptidylpeptidase 6 Gene

Dpp6 - dipeptidylpeptidase 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rw; Dpp-6; Peplb; D5Buc3; D5Buc4; D5Buc5; DPP VI; Gm1377; In(5)6H-p; B930011P16Rik

Gene ID: 13483 | Gene type: protein coding

About Dpp6

Summary

Enables Potassium Channel regulator activity. Involved in protein localization to plasma membrane and regulation of potassium ion transmembrane transport. Acts upstream of or within neuronal action potential and positive regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; intervertebral disc; and nose. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant non-syndromic intellectual disability 33; and spinal muscular atrophy. Orthologous to human DPP6 (Dipeptidyl Peptidase like 6). [provided by Alliance of Genome Resources, Apr 2022]

Dpp6 Products(4)

mRNA Protein Name
NM_001136060.2 NP_001129532.1 dipeptidyl aminopeptidase-like protein 6 isoform 1
NM_001198886.1 NP_001185815.1 dipeptidyl aminopeptidase-like protein 6 isoform 4
NM_010075.2 NP_034205.1 dipeptidyl aminopeptidase-like protein 6 isoform 2
NM_207282.3 NP_997165.2 dipeptidyl aminopeptidase-like protein 6 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
22311982 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24225951 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
21943606 MGI
acts upstream of or within neuronal action potential IMP
IMP: Inferred from mutant phenotype
20573902 MGI
acts upstream of or within positive regulation of potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
21943606 MGI
acts upstream of potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
21943606 MGI
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
22311982 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
20573902 MGI
involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
21943606 MGI
involved in regulation of postsynaptic membrane potential IEP
IEP: Inferred from expression pattern
21943606 MGI
involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
21943606 MGI
involved in regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
22311982 MGI
acts upstream of or within regulation of potassium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
24225951 MGI
acts upstream of or within regulation of potassium ion transport IMP
IMP: Inferred from mutant phenotype
20573902 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
24225951 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22311982 MGI
is active in synapse IDA
IDA: Inferred from direct assay
23912628 MGI
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
19713751 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dipeptidyl aminopeptidase-like protein 6

DPPX

dipeptidyl aminopeptidase-related protein

dipeptidyl peptidase IV-like protein

dipeptidyl peptidase VI

dipeptidylpeptidase VI

inversion, Chr 5, Harwell 6, proximal

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03966 DPP6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21327 Dpp6 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpp6 NCBI NCBI:1804