Dpm2 - dolichol-phosphate (beta-D) mannosyltransferase 2 Gene

About Dpm2

Summary

Predicted to enable dolichyl-phosphate beta-D-mannosyltransferase activity and enzyme activator activity. Predicted to be involved in GPI anchor biosynthetic process and regulation of protein stability. Predicted to act upstream of or within dolichol metabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be integral component of membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex and glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Predicted to colocalize with endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iu. Orthologous to human DPM2 (dolichyl-phosphate mannosyltransferase subunit 2, regulatory). [provided by Alliance of Genome Resources, Apr 2022]