2. Gene
  3. Dpm1 - dolichol-phosphate (beta-D) mannosyltransferase 1 Gene

Dpm1 - dolichol-phosphate (beta-D) mannosyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 13480 | Gene type: protein coding

About Dpm1

Summary

Enables dolichyl-phosphate beta-D-mannosyltransferase activity. Acts upstream of or within GPI anchor biosynthetic process and dolichol metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic). [provided by Alliance of Genome Resources, Apr 2022]

Dpm1 Products(2)

mRNA Protein Name
NM_001310084.1 NP_001297013.1 dolichol-phosphate mannosyltransferase subunit 1 isoform 2
NM_010072.4 NP_034202.1 dolichol-phosphate mannosyltransferase subunit 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables dolichyl-phosphate beta-D-mannosyltransferase activity IMP
IMP: Inferred from mutant phenotype
9535917 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within GPI anchor biosynthetic process IMP
IMP: Inferred from mutant phenotype
9535917 MGI
acts upstream of or within dolichol metabolic process IMP
IMP: Inferred from mutant phenotype
9535917 MGI
acts upstream of or within response to oxygen levels IDA
IDA: Inferred from direct assay
24936167 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dolichol-phosphate mannosyltransferase subunit 1

DPM synthase subunit 1

MPD synthase

dolichol-phosphate mannose synthase subunit 1

dolichyl-phosphate beta-D-mannosyltransferase subunit 1

mannose-P-dolichol synthase subunit 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03958 DPM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22147 Dpm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28668 Dpm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpm1 NCBI NCBI:8813