Dlx3 - distal-less homeobox 3 Gene

Mus musculus

Also known as Dlx-3

Gene ID: 13393 | Gene type: protein coding

About Dlx3

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and chromatin binding activity. Acts upstream of or within several processes, including odontoblast differentiation; odontogenesis of dentin-containing tooth; and placenta development. Located in nucleus. Is expressed in several structures, including brain; branchial arch; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Dlx3 Products(1)

mRNA	Protein	Name
NM_010055.4	NP_034185.1	homeobox protein DLX-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22351765	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18684741	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22351765	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	35922041	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	23371388	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	18684741	MGI
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18684741	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	9874789	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	18684741	MGI
involved in hair cell differentiation	IMP IMP: Inferred from mutant phenotype	18684741	MGI
involved in hair cycle	IMP IMP: Inferred from mutant phenotype	18684741	MGI
involved in hair follicle cell proliferation	IMP IMP: Inferred from mutant phenotype	18684741	MGI
involved in hair follicle development	IMP IMP: Inferred from mutant phenotype	18684741	MGI
involved in hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	18684741	MGI
acts upstream of or within odontoblast differentiation	IMP IMP: Inferred from mutant phenotype	22351765	MGI
involved in odontoblast differentiation	IMP IMP: Inferred from mutant phenotype	22351765	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	22351765	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	9874789	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23371388	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	35922041	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19796622	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein DLX-3

DII C

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03814	DLX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21323	Dlx3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dlx3	NCBI	NCBI:1747

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