Dlx1 - distal-less homeobox 1 Gene

Mus musculus

Also known as Dlx; Dlx-1

Gene ID: 13390 | Gene type: protein coding

About Dlx1

Summary

The protein encoded by this gene is a homeobox-containing transcription factor involved in development. The encoded protein plays a role in craniofacial patterning, as well as in bone, placenta, and sensory organ formation. [provided by RefSeq, Aug 2015]

Dlx1 Products(1)

mRNA	Protein	Name
NM_010053.2	NP_034183.1	homeobox protein DLX-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9415433	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22920256	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14769946	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	14769946	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21875655	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within GABAergic neuron differentiation	IGI IGI: Inferred from genetic interaction	11163262	MGI
acts upstream of Notch signaling pathway	IGI IGI: Inferred from genetic interaction	23042297	MGI
acts upstream of or within cerebral cortex GABAergic interneuron differentiation	IGI IGI: Inferred from genetic interaction	15028753	MGI
acts upstream of or within cerebral cortex GABAergic interneuron fate commitment	IGI IGI: Inferred from genetic interaction	17678855	MGI
acts upstream of or within embryonic skeletal system development	IGI IGI: Inferred from genetic interaction	9187081	MGI
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	9187081	MGI
acts upstream of or within forebrain neuron differentiation	IGI IGI: Inferred from genetic interaction	11163262	MGI
acts upstream of or within hippocampus development	IGI IGI: Inferred from genetic interaction	11163262	MGI
acts upstream of or within negative regulation of Notch signaling pathway	IGI IGI: Inferred from genetic interaction	23042297	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16007083	MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	17678855	MGI
involved in negative regulation of photoreceptor cell differentiation	IMP IMP: Inferred from mutant phenotype	21875655	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17678855	MGI
acts upstream of or within neuroblast differentiation	IMP IMP: Inferred from mutant phenotype	12397111	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16007083	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	9187081	MGI
acts upstream of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	17678855	MGI
involved in positive regulation of amacrine cell differentiation	IMP IMP: Inferred from mutant phenotype	21875655	MGI
involved in positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	21875655	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21875655	MGI
acts upstream of or within proximal/distal pattern formation	IGI IGI: Inferred from genetic interaction	9187081	MGI
acts upstream of or within proximal/distal pattern formation	IMP IMP: Inferred from mutant phenotype	9187081	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22920256	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17678855	MGI
acts upstream of or within subpallium development	IGI IGI: Inferred from genetic interaction	23042297	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10516593	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein DLX-1

DII B

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03812	DLX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20715	Dlx1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27226	Dlx1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dlx1	NCBI	NCBI:1745

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