2. Gene
  3. Dgat1 - diacylglycerol O-acyltransferase 1 Gene

Dgat1 - diacylglycerol O-acyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ARAT; Dgat; D15Ertd23e

Gene ID: 13350 | Gene type: protein coding

About Dgat1

Summary

Enables 2-acylglycerol O-acyltransferase activity and diacylglycerol O-acyltransferase activity. Involved in several processes, including acylglycerol metabolic process; fatty acid homeostasis; and long-chain fatty-acyl-CoA metabolic process. Located in intracellular membrane-bounded organelle and membrane. Is integral component of membrane. Is expressed in several structures, including brain; genitourinary system; integument; liver; and yolk sac. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dgat1 Products(1)

mRNA Protein Name
NM_010046.4 NP_034176.1 diacylglycerol O-acyltransferase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 2-acylglycerol O-acyltransferase activity IDA
IDA: Inferred from direct assay
12077311 MGI
enables diacylglycerol O-acyltransferase activity IDA
IDA: Inferred from direct assay
11481335 MGI
Biological Process GO Annotation Evidence Reference Source
involved in diacylglycerol metabolic process IDA
IDA: Inferred from direct assay
11481335 MGI
involved in fatty acid homeostasis IGI
IGI: Inferred from genetic interaction
18252207 MGI
involved in fatty acid homeostasis IMP
IMP: Inferred from mutant phenotype
10802663 MGI
involved in lipid storage IGI
IGI: Inferred from genetic interaction
21317108 MGI
involved in lipid storage IMP
IMP: Inferred from mutant phenotype
10802663 MGI
involved in long-chain fatty-acyl-CoA metabolic process IDA
IDA: Inferred from direct assay
11481335 MGI
involved in monoacylglycerol biosynthetic process IMP
IMP: Inferred from mutant phenotype
28420705 MGI
involved in triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
11481335 MGI
involved in triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
10802663 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
19049983 MGI
located in intracellular membrane-bounded organelle IMP
IMP: Inferred from mutant phenotype
18252207 MGI
located in membrane IDA
IDA: Inferred from direct assay
10802663 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

diacylglycerol O-acyltransferase 1

acyl-CoA retinol O-fatty-acyltransferase

diglyceride acyltransferase

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-16278 Pradigastat Inhibitor 98.88% Phase 3
HY-13009 PF-04620110 Inhibitor 99.60% Phase 1
HY-15497 AZD7687 Inhibitor 99.80% Phase 1
HY-123765 JTT-553 Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10038 A 922500 Inhibitor 99.33% Unkown
HY-32219 T863 Inhibitor 99.83% Unkown
HY-12425 DGAT1-IN-1 Inhibitor ≥98.0% Unkown
HY-141572 1,2-Dioleoyl-sn-glycerol 99.96% Unkown
HY-50861 AZD3988 Inhibitor 99.83% Unkown
HY-50670 DGAT-1 inhibitor 2 Inhibitor 95.70% Unkown
HY-15197 ABT-046 Inhibitor 98.57% Unkown
HY-16434 DGAT1-IN-3 Inhibitor 99.92% Unkown
HY-111417 GSK2973980A Inhibitor / Unkown
HY-112851 Diacylglycerol acyltransferase inhibitor-1 Inhibitor / Unkown
HY-118386 H2-005 / Unkown
HY-16088 BAY 74-4113 Inhibitor / Unkown
HY-16278A Pradigastat sodium Inhibitor / Unkown
HY-N7281 Aphadilactone C Inhibitor / Unkown
HY-RS03710 DGAT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-136707 DGAT-1 inhibitor 3 Inhibitor / Unkown
HY-16266 JNJ-DGAT1-A Inhibitor / Unkown
HY-N9153A Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether / Unkown
HY-RS16667 Dgat1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23102 Dgat1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dgat1 NCBI NCBI:8694