Twist2 - twist basic helix-loop-helix transcription factor 2 Gene

Mus musculus

Also known as Dermo1; bHLHa39

Gene ID: 13345 | Gene type: protein coding

About Twist2

Summary

Enables DNA-binding transcription factor activity; chromatin binding activity; and protein domain specific binding activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including face morphogenesis; negative regulation of cell differentiation; and negative regulation of macromolecule metabolic process. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in Barber-Say syndrome; ablepharon macrostomia syndrome; and focal dermal hypoplasia. Orthologous to human TWIST2 (twist family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Twist2 Products(1)

mRNA	Protein	Name
NM_007855.3	NP_031881.1	twist-related protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7589808	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16831897	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14654692	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15030764	MGI
enables transcription factor binding	IDA IDA: Inferred from direct assay	14654692	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19090621	MGI
acts upstream of or within cornea development in camera-type eye	IMP IMP: Inferred from mutant phenotype	20574024	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IGI IGI: Inferred from genetic interaction	15030764	MGI
acts upstream of or within face morphogenesis	IMP IMP: Inferred from mutant phenotype	20574024	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	20574024	MGI
acts upstream of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	16831897	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	16831897	MGI
acts upstream of myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	19090621	MGI
acts upstream of or within negative regulation of DNA binding	IDA IDA: Inferred from direct assay	14654692	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7589808	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19090621	MGI
acts upstream of or within negative regulation of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	16831897	MGI
acts upstream of or within negative regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	16831897	MGI
acts upstream of or within negative regulation of molecular function	IDA IDA: Inferred from direct assay	15030764	MGI
acts upstream of or within negative regulation of myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	19090621	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15030764	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16831897	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	14654692	MGI
acts upstream of or within negative regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	16831897	MGI
acts upstream of or within negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16831897	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15030764	MGI
acts upstream of or within positive regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	20574024	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7589808	MGI
acts upstream of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	16831897	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16831897	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	7589808	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

twist-related protein 2

dermis-expressed protein 1

twist homolog 2

Twist2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Twist2	Q9D030	Runx2	Mus musculus	Q08775	Anti Bait CoIP	20655471

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15282	TWIST2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21968	Twist2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Twist2	NCBI	NCBI:117581

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