Asap1 - ArfGAP with SH3 domain, ankyrin repeat and PH domain1 Gene

Mus musculus

Also known as PAP; s19; DEF-1; Ddef1; mKIAA1249

Gene ID: 13196 | Gene type: protein coding

About Asap1

Summary

Enables GTPase activator activity; SH3 domain binding activity; and phospholipid binding activity. Acts upstream of or within negative regulation of dendritic spine development; positive regulation of membrane tubulation; and positive regulation of podosome assembly. Located in cell projection membrane; dendritic spine; and podosome. Is active in cytosol and plasma membrane. Is expressed in several structures, including gonad; limb; long bone; perichondrium; and thoracic duct. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Apr 2022]

Asap1 Products(6)

mRNA	Protein	Name
NM_001276461.2	NP_001263390.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform b
NM_001276462.2	NP_001263391.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform c
NM_001276463.2	NP_001263392.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform d
NM_001276467.2	NP_001263396.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform e
NM_001411185.1	NP_001398114.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform f
NM_010026.4	NP_034156.2	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	10734117	MGI
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	10734117	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	10734117	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	16431365	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9819391	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of dendritic spine development	IDA IDA: Inferred from direct assay	23050017	MGI
acts upstream of or within positive regulation of membrane tubulation	IDA IDA: Inferred from direct assay	16431365	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	23050017	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	23050017	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	23050017	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23050017	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23050017	MGI
located in podosome	IDA IDA: Inferred from direct assay	21352810	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein	130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
ADP-ribosylation factor-directed GTPase-activating protein 1	ARF GTPase-activat

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01055	ASAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20858	Asap1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27373	Asap1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Asap1	NCBI	NCBI:50807

Name
Email *

	Sorry, but the email address you supplied was invalid.