2. Gene
  3. Dag1 - dystroglycan 1 Gene

Dag1 - dystroglycan 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as DG; Dp71; Dp427; D9Wsu13e

Gene ID: 13138 | Gene type: protein coding

About Dag1

Summary

This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the Cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. A complete lack of the encoded protein in mice results in embryonic lethality due to the disorganization of Reichert's membrane. Chimeric mice deficient in the encoded protein overcome embryonic lethality but develop a progressive muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]

Dag1 Products(7)

mRNA Protein Name
NM_001276481.1 NP_001263410.1 dystroglycan 1 preproprotein
NM_001276482.1 NP_001263411.1 dystroglycan 1 preproprotein
NM_001276485.1 NP_001263414.1 dystroglycan 1 preproprotein
NM_001276486.1 NP_001263415.1 dystroglycan 1 preproprotein
NM_001276492.1 NP_001263421.1 dystroglycan 1 preproprotein
NM_001276493.1 NP_001263422.1 dystroglycan 1 preproprotein
NM_010017.4 NP_034147.1 dystroglycan 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables dystroglycan binding IPI
IPI: Inferred from physical interaction
14622018 MGI
enables laminin binding IDA
IDA: Inferred from direct assay
19155270 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10355629 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
19494113 MGI
Biological Process GO Annotation Evidence Reference Source
involved in Schwann cell development IMP
IMP: Inferred from mutant phenotype
12797959 MGI
acts upstream of or within basement membrane organization IMP
IMP: Inferred from mutant phenotype
23217742 MGI
acts upstream of or within branching involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
11798066 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
24753587 MGI
acts upstream of or within commissural neuron axon guidance IMP
IMP: Inferred from mutant phenotype
23217742 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
11798066 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
19797173 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
19797173 MGI
acts upstream of or within morphogenesis of an epithelial sheet IMP
IMP: Inferred from mutant phenotype
11798066 MGI
involved in myelination in peripheral nervous system IMP
IMP: Inferred from mutant phenotype
12797959 MGI
involved in nerve maturation IMP
IMP: Inferred from mutant phenotype
12797959 MGI
acts upstream of or within protein transport IDA
IDA: Inferred from direct assay
24753587 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
27707967 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
27707967 MGI
involved in regulation of synapse organization IDA
IDA: Inferred from direct assay
27707967 MGI
involved in regulation of synapse organization IMP
IMP: Inferred from mutant phenotype
27707967 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
24753587 MGI
acts upstream of or within response to muscle activity IDA
IDA: Inferred from direct assay
24753587 MGI
involved in retrograde trans-synaptic signaling by trans-synaptic protein complex IDA
IDA: Inferred from direct assay
27707967 MGI
involved in retrograde trans-synaptic signaling by trans-synaptic protein complex IMP
IMP: Inferred from mutant phenotype
27707967 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
27707967 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
27707967 MGI
located in basement membrane IDA
IDA: Inferred from direct assay
9524190 MGI
is active in cell surface IDA
IDA: Inferred from direct assay
24753587 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
part of dystroglycan complex IDA
IDA: Inferred from direct assay
11798066 MGI
part of dystroglycan complex IMP
IMP: Inferred from mutant phenotype
14622018 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12797959 MGI
located in membrane IDA
IDA: Inferred from direct assay
23217742 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
11259414 MGI
located in node of Ranvier IMP
IMP: Inferred from mutant phenotype
12797959 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
21129441 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10481911 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
24753587 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
9524190 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dystroglycan 1

dystroglycan

dystrophin associated glycoprotein 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112552 1,2-Distearoyl-sn-glycerol ≥98.0% Phase 3
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W100403 Choline tosylate Inhibitor 99.41% Unkown
HY-RS03519 DAG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18922 Dag1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25412 Dag1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dag1 NCBI NCBI:1605