2. Gene
  3. Cyp8b1 - cytochrome P450, family 8, subfamily b, polypeptide 1 Gene

Cyp8b1 - cytochrome P450, family 8, subfamily b, polypeptide 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 13124 | Gene type: protein coding

About Cyp8b1

Summary

Predicted to enable sterol 12-alpha-hydroxylase activity. Involved in bile acid biosynthetic process and positive regulation of intestinal Cholesterol absorption. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including liver; lung; skeletal muscle; spleen; and testis. Orthologous to human CYP8B1 (Cytochrome P450 family 8 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp8b1 Products(1)

mRNA Protein Name
NM_010012.3 NP_034142.3 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in bile acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
12393855 MGI
involved in positive regulation of intestinal cholesterol absorption IDA
IDA: Inferred from direct assay
12393855 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase

CYPVIIIB1

cytochrome P450 8B1

cytochrome P450, 8b1, sterol 12 alpha-hydrolase

sterol 12-alpha-hydrolase

sterol 12-alpha-hydroxylase

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113259 7α-Hydroxy-4-cholesten-3-one 99.60% Unkown
HY-113259S 7α-Hydroxy-4-cholesten-3-one-d7 ≥98.0% Unkown
HY-113259R 7α-Hydroxy-4-cholesten-3-one (Standard) / Unkown
HY-RS03489 CYP8B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17779 Cyp8b1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24246 Cyp8b1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp8b1 NCBI NCBI:1582