2. Gene
  3. Crmp1 - collapsin response mediator protein 1 Gene

Crmp1 - collapsin response mediator protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as DRP-1; Ulip3; CRMP-1; Dpysl1; ULIP-3

Gene ID: 12933 | Gene type: protein coding

About Crmp1

Summary

This gene encodes a protein that is part of the collapsin response mediator protein family. The family is comprised of five, homologous cytosolic phosphoproteins that are expressed in developing and adult nervous tissue and mediate signaling to transduce responses to extracellular cues. This protein is a Semaphorin 3A signaling molecule that regulates collapse of the growth cone. The growth cone mediates axonal pathfinding in neurons. This protein is reported to represent a new class of microtubule-associated proteins. In humans this protein is reported to inhibit Cancer cell invasion. In mouse deficiency of this gene may be associated with impaired spatial memory performance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Crmp1 Products(2)

mRNA Protein Name
NM_001136058.2 NP_001129530.1 dihydropyrimidinase-related protein 1 isoform 1
NM_007765.4 NP_031791.3 dihydropyrimidinase-related protein 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
10956643 MGI
Biological Process GO Annotation Evidence Reference Source
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
18003833 MGI
involved in regulation of postsynapse assembly IEP
IEP: Inferred from expression pattern
18003833 MGI
involved in semaphorin-plexin signaling pathway IEP
IEP: Inferred from expression pattern
25358863 MGI
involved in semaphorin-plexin signaling pathway IGI
IGI: Inferred from genetic interaction
25358863 MGI
Cellular Component GO Annotation Evidence Reference Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
25358863 MGI
located in dendrite IDA
IDA: Inferred from direct assay
15834957 MGI
located in growth cone IDA
IDA: Inferred from direct assay
25358863 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
15834957 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
18003833 MGI
is active in postsynapse IEP
IEP: Inferred from expression pattern
18003833 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
18003833 MGI
is active in presynapse IEP
IEP: Inferred from expression pattern
18003833 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydropyrimidinase-related protein 1

inactive dihydropyrimidinase

unc-33-like phosphoprotein 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03190 CRMP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19672 Crmp1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26165 Crmp1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crmp1 NCBI NCBI:1400