Creb1 - cAMP responsive element binding protein 1 Gene

Mus musculus

Also known as Creb; Creb-1; 2310001E10Rik; 3526402H21Rik

Gene ID: 12912 | Gene type: protein coding

About Creb1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cAMP response element binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of biosynthetic process; and protein stabilization. Acts upstream of or within several processes, including animal organ development; cellular response to hepatocyte growth factor stimulus; and cellular response to Leukemia Inhibitory Factor. Located in chromatin and nucleus. Part of ATF4-CREB1 transcription factor complex. Is expressed in several structures, including genitourinary system; limb; maxillary process; peripheral nervous system ganglion; and telencephalon. Orthologous to human CREB1 (cAMP responsive element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Creb1 Products(3)

mRNA	Protein	Name
NM_001037726.1	NP_001032815.1	cyclic AMP-responsive element-binding protein 1 isoform C
NM_009952.2	NP_034082.1	cyclic AMP-responsive element-binding protein 1 isoform B
NM_133828.2	NP_598589.2	cyclic AMP-responsive element-binding protein 1 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11354513	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	20876357	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12220541	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28763438	MGI
enables cAMP response element binding	IDA IDA: Inferred from direct assay	23729669	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17550780	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15030764	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	11988169	MGI
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	16427017	MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus	IDA IDA: Inferred from direct assay	21072211	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	20876357	MGI
acts upstream of or within cellular response to zinc ion	IDA IDA: Inferred from direct assay	23716681	MGI
involved in circadian rhythm	IDA IDA: Inferred from direct assay	20852621	MGI
acts upstream of hormone secretion	IMP IMP: Inferred from mutant phenotype	16141355	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	16141355	MGI
acts upstream of or within lung epithelium development	IMP IMP: Inferred from mutant phenotype	21408140	MGI
acts upstream of or within lung saccule development	IMP IMP: Inferred from mutant phenotype	21408140	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	16141355	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	23223304	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	30566056	MGI
acts upstream of osteoclast differentiation	IDA IDA: Inferred from direct assay	23395171	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	16141355	MGI
involved in positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	21728997	MGI
acts upstream of or within positive regulation of cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	24364879	MGI
involved in positive regulation of fat cell differentiation	IGI IGI: Inferred from genetic interaction	21728997	MGI
acts upstream of or within positive regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	16141355	MGI
involved in positive regulation of lipid biosynthetic process	IGI IGI: Inferred from genetic interaction	21728997	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	16141355	MGI
acts upstream of or within positive regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	23395171	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18252718	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20852621	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20876357	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	21728997	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12220541	MGI
acts upstream of or within regulation of cell size	IGI IGI: Inferred from genetic interaction	12015964	MGI
involved in regulation of testosterone biosynthetic process	IDA IDA: Inferred from direct assay	21333348	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12871976	MGI
involved in response to glucagon	IMP IMP: Inferred from mutant phenotype	20852621	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	9098922	MGI
acts upstream of or within secretory granule organization	IMP IMP: Inferred from mutant phenotype	21408140	MGI
acts upstream of or within type I pneumocyte differentiation	IMP IMP: Inferred from mutant phenotype	21408140	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of ATF4-CREB1 transcription factor complex	IDA IDA: Inferred from direct assay	12871976	MGI
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	12871976	MGI
located in chromatin	IDA IDA: Inferred from direct assay	16427017	MGI
located in chromatin	IMP IMP: Inferred from mutant phenotype	20876357	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	21728997	MGI
located in nucleus	IDA IDA: Inferred from direct assay	7565774	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	11354513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cyclic AMP-responsive element-binding protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03148	CREB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P4497	Prolylserine		/	Unkown
HY-RS18270	Creb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24748	Creb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Creb1	NCBI	NCBI:1385

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