2. Gene
  3. Cplx1 - complexin 1 Gene

Cplx1 - complexin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 921-S

Gene ID: 12889 | Gene type: protein coding

About Cplx1

Summary

Enables neurotransmitter transmembrane transporter activity. Involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane and secretion by cell. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Part of SNARE complex. Is active in calyx of Held. Is expressed in nervous system; retina; and tongue. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 63. Orthologous to human CPLX1 (complexin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cplx1 Products(1)

mRNA Protein Name
NM_007756.3 NP_031782.3 complexin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lipid binding EXP
EXP: Inferred from Experiment
35777466 MGI
Biological Process GO Annotation Evidence Reference Source
involved in insulin secretion IMP
IMP: Inferred from mutant phenotype
15126625 MGI
involved in regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane IDA
IDA: Inferred from direct assay
22284181 MGI
involved in regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
22284181 MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane IDA
IDA: Inferred from direct assay
11163241 MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
IMP: Inferred from mutant phenotype
11163241 MGI
involved in synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
15126625 MGI
Cellular Component GO Annotation Evidence Reference Source
part of SNARE complex IDA
IDA: Inferred from direct assay
15126625 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
22284181 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
22284181 MGI
is active in calyx of Held IDA
IDA: Inferred from direct assay
26019341 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11163241 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
11163241 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
26019341 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
26019341 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complexin-1

CPX I

complexin I

synaphin-2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03097 CPLX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22455 Cplx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28978 Cplx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cplx1 NCBI NCBI:10815