2. Gene
  3. Col4a3 - collagen, type IV, alpha 3 Gene

Col4a3 - collagen, type IV, alpha 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as [a]3(IV); alpha3(IV)

Gene ID: 12828 | Gene type: protein coding

About Col4a3

Summary

Predicted to enable Integrin binding activity. Predicted to be an extracellular matrix structural constituent. Involved in cell surface receptor signaling pathway; glomerular basement membrane development; and negative regulation of angiogenesis. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in basement membrane. Part of Collagen type IV trimer. Is expressed in several structures, including cardiovascular system; eye; foregut; genitourinary system; and trachea. Used to study autosomal recessive Alport syndrome. Human ortholog(s) of this gene implicated in Alport syndrome; autosomal dominant Alport syndrome; autosomal recessive Alport syndrome; benign familial hematuria; and end stage renal disease. Orthologous to human COL4A3 (Collagen type IV alpha 3 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col4a3 Products(1)

mRNA Protein Name
NM_007734.3 NP_031760.2 collagen alpha-3(IV) chain precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
12842087 MGI
acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway IGI
IGI: Inferred from genetic interaction
10970885 MGI
involved in glomerular basement membrane development IMP
IMP: Inferred from mutant phenotype
12631063 MGI
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
16877525 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basement membrane IDA
IDA: Inferred from direct assay
11732842 MGI
part of collagen type IV trimer IDA
IDA: Inferred from direct assay
12101409 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-3(IV) chain

collagen type IV alpha3 chain

procollagen, type IV, alpha 3

tumstatin

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02985 COL4A3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18420 Col4a3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24901 Col4a3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col4a3 NCBI NCBI:1285
Rattus norvegicus Col4a3 NCBI NCBI:363265