2. Gene
  3. Col4a2 - collagen, type IV, alpha 2 Gene

Col4a2 - collagen, type IV, alpha 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Col4a-2

Gene ID: 12827 | Gene type: protein coding

About Col4a2

Summary

This gene encodes the alpha-2 subunit of the type IV collagens, an essential component of basement membranes. The encoded protein forms a triple helical heterotrimer comprised of alpha-1 and alpha-2 subunits that assembles into a type IV Collagen network. Canstatin, a peptide derived fom the C-terminus of the Collagen chain, is a matrikine that has been shown to inhibit angiogenesis. Homozygous knockout mice for this gene exhibit impaired basement membrane integrity and embryonic lethality. This gene shares a bi-directional promoter with a related gene on chromosome 8. [provided by RefSeq, Nov 2015]

Col4a2 Products(1)

mRNA Protein Name
NM_009932.4 NP_034062.3 collagen alpha-2(IV) chain precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in DNA-templated transcription IDA
IDA: Inferred from direct assay
17525254 MGI
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
17525254 MGI
acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway IGI
IGI: Inferred from genetic interaction
10970885 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basement membrane IDA
IDA: Inferred from direct assay
11732842 MGI
part of collagen type IV trimer IDA
IDA: Inferred from direct assay
12101409 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-2(IV) chain

canstatin

procollagen, type IV, alpha 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02984 COL4A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18703 Col4a2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25190 Col4a2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col4a2 NCBI NCBI:1284