2. Gene
  3. Cntfr - ciliary neurotrophic factor receptor Gene

Cntfr - ciliary neurotrophic factor receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cntfralpha

Gene ID: 12804 | Gene type: protein coding

About Cntfr

Summary

This gene encodes the alpha subunit of the ciliary neurotrophic factor (CNTF) receptor that triggers the assembly of a trimolecular complex upon binding to CNTF, and initiate a downstream signaling process. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-linked cell surface protein. Mice lacking the encoded protein die shortly after birth and exhibit a reduction of motoneuron number at birth. The transgenic disruption of this gene specifically in the skeletal muscle followed by a peripheral nerve lesion impairs motor neuron axonal regeneration across the lesion site. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Cntfr Products(10)

mRNA Protein Name
NM_001136056.4 NP_001129528.1 ciliary neurotrophic factor receptor subunit alpha preproprotein
NM_001379211.1 NP_001366140.1 ciliary neurotrophic factor receptor subunit alpha preproprotein
NM_001379212.1 NP_001366141.1 ciliary neurotrophic factor receptor subunit alpha preproprotein
NM_001379213.1 NP_001366142.1 ciliary neurotrophic factor receptor subunit alpha preproprotein
NM_001379214.1 NP_001366143.1 ciliary neurotrophic factor receptor subunit alpha preproprotein
NM_001379215.1 NP_001366144.1 ciliary neurotrophic factor receptor subunit alpha preproprotein
NM_001379216.1 NP_001366145.1 ciliary neurotrophic factor receptor subunit alpha preproprotein
NM_001403746.1 NP_001390675.1 ciliary neurotrophic factor receptor subunit alpha precursor
NM_001403747.1 NP_001390676.1 ciliary neurotrophic factor receptor subunit alpha precursor
NM_016673.3 NP_057882.2 ciliary neurotrophic factor receptor subunit alpha preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ciliary neurotrophic factor receptor activity IGI
IGI: Inferred from genetic interaction
7585948 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15051883 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within brainstem development IMP
IMP: Inferred from mutant phenotype
7585948 MGI
acts upstream of or within ciliary neurotrophic factor-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
7585948 MGI
acts upstream of motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11312299 MGI
acts upstream of or within negative regulation of motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11312299 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
15051883 MGI
acts upstream of or within sex differentiation IMP
IMP: Inferred from mutant phenotype
10526311 MGI
acts upstream of or within skeletal muscle organ development IMP
IMP: Inferred from mutant phenotype
10526311 MGI
acts upstream of or within suckling behavior IMP
IMP: Inferred from mutant phenotype
7585948 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ciliary neurotrophic factor receptor subunit alpha

CNTF receptor subunit alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02924 CNTFR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18513 Cntfr Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24995 Cntfr Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cntfr NCBI NCBI:1271
Rattus norvegicus Cntfr NCBI NCBI:313173