2. Gene
  3. Abcc2 - ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Gene

Abcc2 - ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mrp2; cMRP; Abc30; Cmoat

Gene ID: 12780 | Gene type: protein coding

About Abcc2

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the canalicular surface of the hepatocyte and in biliary transport, and appears to contribute to drug resistance in mammalian cells. Several different mutations in the human gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Alternative splice variants have been observed for this gene; however, they have not been fully described. [provided by RefSeq, Jul 2008]

Abcc2 Products(1)

mRNA Protein Name
NM_013806.2 NP_038834.2 ATP-binding cassette sub-family C member 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12068294 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12951053 MGI
located in intercellular canaliculus IDA
IDA: Inferred from direct assay
12068294 MGI
located in membrane IDA
IDA: Inferred from direct assay
11279518 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12951053 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family C member 2

canalicular multispecific organic anion transporter 1

multidrug resistance protein 2

multidrug resistance-associated protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00061 ABCC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21468 Abcc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27986 Abcc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcc2 NCBI NCBI:1244