Clock - circadian locomotor output cycles kaput Gene

Mus musculus

Also known as KAT13D; 5330400M04Rik

Gene ID: 12753 | Gene type: protein coding

About Clock

Summary

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding Histone Acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]

Clock Products(3)

mRNA	Protein	Name
NM_001289826.1	NP_001276755.1	circadian locomoter output cycles protein kaput isoform 1
NM_001305222.1	NP_001292151.1	circadian locomoter output cycles protein kaput isoform 2
NM_007715.6	NP_031741.1	circadian locomoter output cycles protein kaput isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15560782	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12024206	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15147242	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	12738229	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15147242	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	24610784	MGI
enables histone acetyltransferase activity	IMP IMP: Inferred from mutant phenotype	19141540	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9704006	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21613214	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	14672706	MGI
acts upstream of or within circadian rhythm	IDA IDA: Inferred from direct assay	12897057	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	14645221	MGI
acts upstream of or within circadian rhythm	IMP IMP: Inferred from mutant phenotype	8171325	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	24378737	MGI
involved in negative regulation of glucocorticoid receptor signaling pathway	IDA IDA: Inferred from direct assay	24378737	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12397359	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20430893	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	22895791	MGI
involved in positive regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	22653727	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	22894897	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19217292	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14672706	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16606840	MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	23395176	MGI
involved in protein acetylation	IDA IDA: Inferred from direct assay	28985504	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12024206	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22653727	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	30012868	MGI
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	20562852	MGI
involved in regulation of type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	20562852	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	22900038	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of CLOCK-BMAL transcription complex	IPI IPI: Inferred from physical interaction	22653727	MGI
located in chromatoid body	IDA IDA: Inferred from direct assay	22900038	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12897057	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12897057	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	16606840	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

circadian locomoter output cycles protein kaput

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148765	CLK8	Inhibitor	98.06%	Unkown
HY-115672	KS15	Inhibitor	99.46%	Unkown
HY-115519	(E/Z)-GO289	Inhibitor	98.98%	Unkown
HY-119506	KL044		99.05%	Unkown
HY-134194	KL201		98.18%	Unkown
HY-145149	Duostatin 5		99.76%	Unkown
HY-RS02828	CLOCK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W011425	NTPO		/	Unkown
HY-RS17250	Clock Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23704	Clock Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Clock	NCBI	NCBI:9575

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