2. Gene
  3. Cldn1 - claudin 1 Gene

Cldn1 - claudin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 12737 | Gene type: protein coding

About Cldn1

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene die soon after birth as a consequence of dehydration from trandermal water loss, indicating that this gene is indispensable for creating and maintaining the epidermal barrier. The protein encoded by this gene also has gastric tumor suppressive activity, and is a key factor for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010]

Cldn1 Products(1)

mRNA Protein Name
NM_016674.4 NP_057883.1 claudin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
10562289 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10562289 MGI
Biological Process GO Annotation Evidence Reference Source
involved in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
IDA: Inferred from direct assay
10508613 MGI
involved in cell junction maintenance IMP
IMP: Inferred from mutant phenotype
12734665 MGI
involved in establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
11889141 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
20089884 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
9647647 MGI
located in cell junction IDA
IDA: Inferred from direct assay
21983942 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
12734665 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
22275141 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11889141 MGI
located in tight junction IDA
IDA: Inferred from direct assay
30734065 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-1

Related Agents

Pre-clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991200 OM-7D3-B3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn1 NCBI NCBI:9076
Macaca fascicularis Cldn1 NCBI NCBI:102136275