Vsx2 - visual system homeobox 2 Gene

Mus musculus

Also known as or; Chx10; Hox10; Hox-10

Gene ID: 12677 | Gene type: protein coding

About Vsx2

Summary

This gene encodes a member of the Vsx (visual system homeobox) family which belongs to the larger PRD homeobox class. The encoded protein is required for eye organogenesis and controls retinal development. Disruption of this gene is associated with ocular retardation J (orJ), a mouse disease which causes microphthalmia, retinal degeneration and optic nerve aplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Vsx2 Products(2)

mRNA	Protein	Name
NM_001301427.1	NP_001288356.1	visual system homeobox 2 isoform 1
NM_007701.3	NP_031727.1	visual system homeobox 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9464541	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	15576400	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	15576400	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8630490	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16384989	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16384989	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8630490	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15767664	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	8630490	MGI
acts upstream of or within retinal bipolar neuron differentiation	IMP IMP: Inferred from mutant phenotype	8630490	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15767664	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	10482234	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15767664	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

visual system homeobox 2

C. elegans ceh-10 homeo domain containing homolog	ceh-10 homeodomain-containing homolog
homeobox protein CHX10	ocular retardation

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W009310	9-cis-Retinal		99.29%	Unkown
HY-RS15719	VSX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19973	Vsx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26476	Vsx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vsx2	NCBI	NCBI:338917

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