Chrm3 - cholinergic receptor, muscarinic 3, cardiac Gene

Mus musculus

Also known as M3; M3R; Chrm-3

Gene ID: 12671 | Gene type: protein coding

About Chrm3

Summary

Predicted to enable several functions, including G protein-coupled acetylcholine receptor binding activity; G protein-coupled amine receptor activity; and acetylcholine binding activity. Acts upstream of or within several processes, including cholinergic synaptic transmission; positive regulation of smooth muscle contraction; and saliva secretion. Predicted to be located in asymmetric synapse; axon terminus; and basal plasma membrane. Predicted to be active in dendrite and synapse. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Apr 2022]

Chrm3 Products(1)

mRNA	Protein	Name
NM_033269.4	NP_150372.1	muscarinic acetylcholine receptor M3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled acetylcholine receptor activity	IDA IDA: Inferred from direct assay	20440069	MGI
enables G protein-coupled acetylcholine receptor activity	IMP IMP: Inferred from mutant phenotype	16753580	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19575010	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ion channel modulating, G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	20440069	MGI
involved in ligand-gated ion channel signaling pathway	IDA IDA: Inferred from direct assay	20440069	MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	20440069	MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16753580	MGI
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	20440069	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	16753580	MGI
acts upstream of or within positive regulation of smooth muscle contraction	IDA IDA: Inferred from direct assay	12925702	MGI
acts upstream of or within saliva secretion	IMP IMP: Inferred from mutant phenotype	10944224	MGI
acts upstream of smooth muscle contraction	IDA IDA: Inferred from direct assay	12925702	MGI
acts upstream of or within smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	10944224	MGI
acts upstream of or within synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	10944224	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	20440069	MGI
is active in plasma membrane	IMP IMP: Inferred from mutant phenotype	16753580	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

muscarinic acetylcholine receptor M3

AChR M3	mm3 mAChR
muscarinic acetylcholine receptor 3

Chrm3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81142	Muscarinic Acetylcholine receptor M3 Antibody (YA3525)	WB	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02662	CHRM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19180	Chrm3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25668	Chrm3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrm3	NCBI	NCBI:1131

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