Cfl1 - cofilin 1, non-muscle Gene

Mus musculus

Also known as Cof

Gene ID: 12631 | Gene type: protein coding

About Cfl1

Summary

Enables actin filament binding activity and signaling receptor binding activity. Involved in Cytoskeleton organization; positive regulation of actin filament depolymerization; and positive regulation of embryonic development. Acts upstream of or within several processes, including neural crest cell migration; neural fold formation; and response to amino acid. Located in cell-cell junction; cortical actin cytoskeleton; and lamellipodium. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and immune system. Orthologous to human CFL1 (cofilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cfl1 Products(1)

mRNA	Protein	Name
NM_007687.5	NP_031713.1	cofilin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	11809832	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25208553	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	24052308	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament depolymerization	IDA IDA: Inferred from direct assay	11809832	MGI
involved in actin filament fragmentation	IDA IDA: Inferred from direct assay	11809832	MGI
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	15649475	MGI
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	25208553	MGI
acts upstream of or within cell motility	IMP IMP: Inferred from mutant phenotype	15548599	MGI
acts upstream of or within establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	15649475	MGI
involved in establishment of spindle localization	IMP IMP: Inferred from mutant phenotype	25208553	MGI
acts upstream of or within mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	15548599	MGI
acts upstream of or within neural crest cell migration	IMP IMP: Inferred from mutant phenotype	15649475	MGI
acts upstream of or within neural fold formation	IMP IMP: Inferred from mutant phenotype	15649475	MGI
involved in positive regulation of actin filament depolymerization	IDA IDA: Inferred from direct assay	23921380	MGI
acts upstream of or within positive regulation of actin filament depolymerization	IMP IMP: Inferred from mutant phenotype	15548599	MGI
involved in positive regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	25208553	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	17018287	MGI
acts upstream of or within response to amino acid	IDA IDA: Inferred from direct assay	17018287	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	15004221	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15548599	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16388910	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	25107909	MGI
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	16388910	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cofilin-1

n-cofilin

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02568	CFL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18607	Cfl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25093	Cfl1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cfl1	NCBI	NCBI:1072

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