Cebpb - CCAAT/enhancer binding protein (C/EBP), beta Gene

Mus musculus

Also known as LAP; LIP; CRP2; NF-M; Nfil6; NF-IL6; IL-6DBP; C/EBPbeta

Gene ID: 12608 | Gene type: protein coding

About Cebpb

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and enzyme binding activity. Contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including liver development; regulation of leukocyte differentiation; and response to bacterium. Acts upstream of or within several processes, including mammary gland epithelium development; positive regulation of osteoblast differentiation; and regulation of gene expression. Located in chromosome; cytoplasm; and nuclear matrix. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including adrenal gland; alimentary system; extraembryonic component; genitourinary system; and integumental system. Used to study cleidocranial dysplasia and viral infectious disease. Orthologous to human CEBPB (CCAAT enhancer binding protein beta). [provided by Alliance of Genome Resources, Apr 2022]

Cebpb Products(3)

mRNA	Protein	Name
NM_001287738.1	NP_001274667.1	CCAAT/enhancer-binding protein beta isoform b
NM_001287739.1	NP_001274668.1	CCAAT/enhancer-binding protein beta isoform c
NM_009883.4	NP_034013.1	CCAAT/enhancer-binding protein beta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10510303	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10588870	MGI
contributes to DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	27812542	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19641492	MGI
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27812542	MGI
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25472717	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	25921091	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	21122806	MGI
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	17301242	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	18486321	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	12177065	MGI
enables kinase binding	IPI IPI: Inferred from physical interaction	10635333	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11684016	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10588870	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	24216764	MGI
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	24061474	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T-helper 1 cell activation	IMP IMP: Inferred from mutant phenotype	17911624	MGI
involved in brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	19641492	MGI
acts upstream of or within cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	20548288	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	17911624	MGI
acts upstream of or within embryonic placenta development	IGI IGI: Inferred from genetic interaction	15509779	MGI
acts upstream of or within fat cell differentiation	IDA IDA: Inferred from direct assay	15509789	MGI
acts upstream of or within fat cell differentiation	IGI IGI: Inferred from genetic interaction	17888405	MGI
involved in granuloma formation	IMP IMP: Inferred from mutant phenotype	17911624	MGI
involved in hepatocyte proliferation	IDA IDA: Inferred from direct assay	10635333	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	9531536	MGI
involved in liver regeneration	IMP IMP: Inferred from mutant phenotype	9727068	MGI
acts upstream of or within mammary gland epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	10707954	MGI
acts upstream of or within mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10683373	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15175325	MGI
involved in negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	16585579	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	11684016	MGI
acts upstream of or within neuron differentiation	IDA IDA: Inferred from direct assay	11733516	MGI
involved in ovarian follicle development	IMP IMP: Inferred from mutant phenotype	9303532	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15870285	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	15762841	MGI
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	19324970	MGI
involved in positive regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	26526992	MGI
involved in positive regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	16585579	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15175325	MGI
involved in positive regulation of transcription by RNA polymerase II	EXP EXP: Inferred from Experiment	11792321	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10859308	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18486321	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22078933	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25472717	MGI
involved in regulation of dendritic cell differentiation	IGI IGI: Inferred from genetic interaction	26526992	MGI
acts upstream of or within regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	11976687	MGI
involved in regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	19440205	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19324970	MGI
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	17724128	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10859308	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22078933	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of C/EBP complex	IPI IPI: Inferred from physical interaction	17264204	MGI
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	11792321	MGI
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	27812542	MGI
located in chromatin	IDA IDA: Inferred from direct assay	15187136	MGI
located in condensed chromosome, centromeric region	IDA IDA: Inferred from direct assay	21122806	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11684016	MGI
located in nuclear matrix	IDA IDA: Inferred from direct assay	21122806	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10588870	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CCAAT/enhancer-binding protein beta

AGP/EBP	C/EBP BETA
interleukin-6-dependent-binding protein	liver-enriched transcriptional activator
nuclear protein Il6

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02446	CEBPB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17419	Cebpb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23873	Cebpb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cebpb	NCBI	NCBI:1051

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